A Novel Concept of Fundus-Ovary-Salpinx-Para-Aorta Implantation Promoting Unit during Human Embryo Implantation
A Novel Concept of Fundus-Ovary-Salpinx-Para-Aorta Implantation Promoting Unit during Human Embryo Implantation
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DOI：
10.5772/60634
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发表时间：
2015-10
期刊：
影响因子：
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通讯作者：
H. Fujiwara;Y. Araki;S. Saito;Satoru Kyo Kazuhiko Imakawa;M. Shigeta;M. Shiotani;A. Horie;T. Mori
中科院分区：
文献类型：
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作者：
H. Fujiwara;Y. Araki;S. Saito;Satoru Kyo Kazuhiko Imakawa;M. Shigeta;M. Shiotani;A. Horie;T. Mori
人类胚胎着床主要受内分泌系统调节。由于卵巢、输卵管和宫底可以通过输卵管系膜和卵巢韧带直接连通，因此认为发育胚胎途径中的孕酮局部浓度高于全身血液循环中的浓度。免疫系统通过刺激卵巢产生孕酮和诱导子宫内膜分化来促进胚胎着床。免疫系统通过主动脉旁淋巴结识别输卵管中发育中的胚胎。基于上述证据，体外激活的自体免疫细胞被证明可以提高反复种植失败患者的临床妊娠率。此外，自主神经系统，从主动脉旁区域支配的底部，卵巢和输卵管被提出来调节发育胚胎的通路的环境。根据这些发现，我们推测在发育中的胚胎通路中存在一个独特的促进人类胚胎着床的单侧功能单元，包括腹主动脉旁区域，并建议将这个新的功能单元命名为Fundus-Ovary-Salpinx-Para-aortic Implantation Promoting unit（FOSPa-IP unit）。
Human embryo implantation is mainly regulated by the endocrine system. Since the ovary, fallopian tube, and fundus can directly communicate through the mesosalpinx and ovarian ligament, the local concentration of progesterone in the pathway of the developing embryo is considered to be higher than in systemic blood circulation. The immune system promotes embryo implantation by stimulating progesterone production of the ovary and by inducing endometrial differentiation. The recognition of the developing embryo in the fallopian tube by the immune system is achieved through the para-aortic lymph nodes. On the basis of the above evidence, the autologous immune cells activated in vitro were demonstrated to improve clinical pregnancy rates in patients with repeated implantation failures. In addition, the autonomic nerve system that innervates the fundus, the ovary, and the fallopian tube from the para-aortic region is proposed to regulate the environment of the pathway of the developing embryo. From these findings, we suppose that a unique unilateral functional unit to promote human embryo implantation exists in the pathway of the developing embryo including the para-aortic regions and propose naming this novel functional unit the Fundus-Ovary-Salpinx-Para-aorta Implantation Promoting unit (FOSPa-IP unit).