Ruthenium-Catalyzed Urea Synthesis Using Methanol as the C1 Source
Ruthenium-Catalyzed Urea Synthesis Using Methanol as the C1 Source
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DOI：
10.1021/acs.orglett.5b03328
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发表时间：
2016-01-15
期刊：
影响因子：
5.2
通讯作者：
Hong, Soon Hyeok
中科院分区：
文献类型：
--
作者：
Kim, Seung Hyo;Hong, Soon Hyeok
完成了一个前所未有的直接从甲醇和胺合成尿素的方案。该反应是高度原子经济的，产生氢作为唯一的副产物。用市售的钌螯合物作为催化剂。此外，不需要任何添加剂，如碱、氧化剂或氢受体。此外，通过一锅两步反应成功制备了不对称尿素衍生物
An unprecedented protocol for urea synthesis directly from methanol and amine was accomplished. The reaction is highly atom-economical, producing hydrogen as the sole byproduct. Commercially available ruthenium pincer complexes were used as catalysts. In addition, no additive, such as a base, oxidant, or hydrogen acceptor, was required. Furthermore, unsymmetrical urea derivatives were successfully obtained via a one-pot, two-step reaction