Determinants of quality of life in Brazilian patients with Parkinson's disease
Determinants of quality of life in Brazilian patients with Parkinson's disease
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DOI：
10.1002/mds.21408
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发表时间：
2007-07-30
影响因子：
8.6
通讯作者：
Martinez-Martin, Pablo
中科院分区：
文献类型：
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作者：
Carod-Artal, Francisco Javier;Vargas, Antonio Pedro;Martinez-Martin, Pablo
我们的目的是确定一组巴西帕金森病（PD）患者健康相关生活质量（HRQoL）的决定因素。采用Hoehn和Yahr分期（H&Y）、统一帕金森病评定量表（UMRS）、Schwab和England量表（S&E）、简易精神状态检查量表、老年抑郁量表和医院焦虑和抑郁量表（HADS）对患者进行评估。使用MOS简表36（SF-36）、帕金森病问卷（PDQ-39）和帕金森病结局量表-心理社会问卷（SCOPA-PS）评估HRQol。对144名患者进行了评估（平均年龄62岁; 53.5%为男性;平均病程6.6年;中位数H&Y，2（范围：1-4））。平均SCOPA-PS和PDQ-39综合指数（SI）分别为39.2和40.7。PDQ-39和SCOPA-PS SI均与H&Y、S&E、总BMI、HADS分量表和SF-36身心成分中度相关（r = 0.30-0.50）。PDQ-39与SCOPA-PS密切相关（r = 0.73）。HRQoL显着恶化H&Y进展，作为一个整体。在多变量分析模型中，情绪障碍、残疾、运动并发症和教育是HRQoL的独立预测因素。在巴西PD患者中，HRQoL与各种严重程度指标显著相关。抑郁是HRQoL最一致的决定因素，其次是残疾、运动并发症和受教育年限。PDQ-39和SCOPA-PS总分之间存在密切关联。(c)2007年，《社会运动》创刊。
Our objective was to identify determinants of health-related quality of life (HRQoL) in a cohort of Brazilian patients with Parkinson's disease (PD). Patients were evaluated by means of the Hoehn and Yahr staging (H&Y), Unified Parkinson's Disease Rating Scale (UPDRS), Schwab and England scale (S&E), Mini-Mental State Exam, Geriatric Depression Scale, and Hospital Anxiety and Depression Scale (HADS). HRQol was assessed using the MOS-Short-Form 36 (SF-36), the Parkinson's disease Questionnaire (PDQ-39), and the Scales for Outcomes in Parkinson's Disease-Psychosocial Questionnaire (SCOPA-PS). 144 patients were evaluated (mean age 62 years; 53.5% men; mean duration of illness 6.6 years; median H&Y, 2 (range: 1-4). Mean SCOPA-PS and PDQ-39 Summary Index (SI) were 39.2 and 40.7, respectively. Both, PDQ-39 and SCOPA-PS SIs correlated at a moderate level (r = 0.30-0.50) with H&Y, S&E, total UPDRS, HADS subscales, and SF-36 Physical and Mental Components. PDQ-39 and SCOPA-PS were closely associated (r = 0.73). HRQoL significantly deteriorated as H&Y progressed, as a whole. Mood disturbances, disability, motor complications, and education were independent predictors of HRQoL in the multivariate analysis model. In PD Brazilian patients, HRQoL correlated significantly with diverse measures of severity. Depression showed to be the most consistent determinant of HRQoL, followed by disability, motor complications, and education years. There was a close association between the PDQ-39 and SCOPA-PS summary scores. (c) 2007 Movement Disorder Society.