Invitation Cards during Pregnancy Enhance Male Partner Involvement in Prevention of Mother to Child Transmission (PMTCT) of Human Immunodeficiency Virus (HIV) in Blantyre, Malawi: A Randomized Controlled Open Label Trial
Invitation Cards during Pregnancy Enhance Male Partner Involvement in Prevention of Mother to Child Transmission (PMTCT) of Human Immunodeficiency Virus (HIV) in Blantyre, Malawi: A Randomized Controlled Open Label Trial
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DOI：
10.1371/journal.pone.0119273
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发表时间：
2015-03-03
期刊：
影响因子：
3.7
通讯作者：
Muula, Adamson Sinjani
中科院分区：
文献类型：
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作者：
Nyondo, Alinane Linda;Choko, Augustine Talumba;Muula, Adamson Sinjani
男性参与(MI)对于采用预防母婴传播(PMTCT)人类免疫缺陷病毒(HIV)干预措施至关重要。合作伙伴通知(PN)是预防母婴传播服务中确定的MI策略之一。这项随机对照试验的目的是通过比较干预组和非干预组中有伴侣陪同的孕妇的比例，来评估邀请男性伴侣作为预防母婴传播服务中MI的策略的有效性。方法2013年6月至12月，在马拉维布兰太尔的南伦祖和姆彭巴保健中心，孕妇在没有男性伴侣的情况下接受产前护理。在意向治疗分析中，我们比较了邀请卡组和标准护理(SOC)组中随机抽取的所有参与者。结果在462名随机选择的女性中，邀请卡组中65/230(28.26%)的妇女与伴侣一起到产前保健诊所报到，而在SOC组中只有44/232(18.97%)的妇女报告了这一情况。在一项未调整的意向治疗分析中，邀请卡组的女性由男性伴侣陪伴的可能性比SOC组的女性高50%，RR：1.49(95%CI：1.06-2.09)；p=0.02。随机效应分析显示，招募地点的相关系数(ICC)为1.98×10(-3)(95%CI：1.78×10(-7)-0.96×10(-1))，P=0.403。邀请函是PMTCT中MI的一种可行策略。
IntroductionMale involvement (MI) is vital for the uptake of Prevention of Mother to Child Transmission (PMTCT) of Human Immunodeficiency Virus (HIV) interventions. Partner notification (PN) is among the strategies identified for MI in PMTCT services. The purpose of this randomized controlled trial was to evaluate the efficacy of an invitation card to the male partners as a strategy for MI in PMTCT services by comparing the proportion of pregnant women that were accompanied by their partners between the intervention and the non-intervention study groups.MethodsPregnant women attending antenatal care without a male partner at South Lunzu and Mpemba health centres in Blantyre, Malawi, were enrolled in the study from June to December 2013. In an intention-to-treat analysis, we compared all participants that were randomized in the invitation card group with the standard of care (SoC) group. Risk ratios (RR) with 95% confidence intervals (CI) were computed to assess the efficacy of the invitation card.ResultsOf the 462 randomized women, 65/230 (28.26%) of the women in the invitation card group reported to the antenatal care clinic with their partners compared to 44/232 (18.97%) women in the SoC group. In an unadjusted intention-to-treat analysis women in the invitation card group were 50% more likely to be accompanied by their male partners than those in the SoC group RR: 1.49 (95% CI: 1.06-2.09); p = 0.02. Our random effects analysis showed that there was no clustering by site of recruitment with an inter cluster correlation coefficient (ICC) of 1.98 x 10(-3), (95% CI: 1.78 x 10(-7) - 0.96 x 10(-1)); p = 0.403.ConclusionAn invitation card significantly increased the proportion of women who were accompanied by their male partners for the PMTCT services. An invitation card is a feasible strategy for MI in PMTCT.