Pulmonary lymphangioleiomyomatosis: Correlation of ventilation-perfusion scintigraphy, chest radiography, and CT with pulmonary function tests
Pulmonary lymphangioleiomyomatosis: Correlation of ventilation-perfusion scintigraphy, chest radiography, and CT with pulmonary function tests
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DOI：
10.1148/radiology.214.2.r00fe41441
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发表时间：
2000-02-01
期刊：
影响因子：
19.7
通讯作者：
Moss, J
中科院分区：
文献类型：
--
作者：
Avila, NA;Chen, CC;Moss, J
目得：目的：探讨肺通气-灌注（V-P）造影、CT及胸片与肺功能检查结果的相关性。方法：对39例患者进行V-P造影、胸片、常规及薄层CT及肺功能检查。结果：92%的肺通气显像、92%的肺灌注显像、79%的胸片、100%的CT扫描和100%的薄层CT扫描发现影像学异常。在通气描记图上，28例（72%）患者表现出斑点状模式。CT扫描，所有患者都有肺囊肿。单因素分析显示，胸片和CT显示的病变范围、囊肿大小、V-P异常和斑点程度与一秒用力呼气量（FEV 1）、肺一氧化碳弥散量和FEV 1与用力肺活量（FVC）的比值呈负相关（P <0.01），但与FVC和总肺容量无关。较大的囊肿大小与CT显示的病变范围相关，但不显著（P = 0.056）。结论：大多数淋巴管平滑肌瘤病患者存在闪烁照相和放射学异常。在肺通气造影图上，常见的斑点状改变可能与肺囊肿内放射性核素的积聚有关，这是CT上该病的一个标志。每种成像方式的结果与某些肺功能相关。
PURPOSE: To determine the findings on ventilation-perfusion (V-P) scintigrams, computed tomographic (CT) scans, and chest radiographs and correlate them with pulmonary function test results in patients with lymphangioleiomyomatosis.MATERIALS AND METHODS: V-P scintigraphy, chest radiography, conventional and thin-section CT, and pulmonary function tests were performed in 39 patients. The images were graded on a scale of 0 (normal) to 3 (severely abnormal).RESULTS: Imaging abnormalities were found on 92% of ventilation scintigrams, 92% of perfusion scintigrams, 79% of chest radiographs, 100% of CT scans, and 100% of thin-section CT scans. On ventilation scintigrams, 28 (72%) patients demonstrated a speckling pattern. On CT scans, all patients had pulmonary cysts. Univariate analysis showed that extent of disease on chest radiographs and CT scans, cyst size, V-P abnormalities, and degree of speckling were inversely correlated with forced expiratory volume in one second (FEV1), diffusing capacity of lung for carbon monoxide, and the ratio of FEV1 to forced vital capacity (FVC) (P < .01) but not with FVC and total lung capacity. Larger cyst size correlated with extent of disease at CT, but not significantly (P = .056).CONCLUSION: Scintigraphic and radiologic abnormalities are seen in a majority of patients with lymphangioleiomyomatosis. On ventilation scintigrams, a frequently seen speckling pattern may be related to accumulation of radionuclide in pulmonary cysts-a hallmark of the disease at CT. Findings with each imaging modality correlate with certain pulmonary functions.