Variation of 52 new Y-STR loci in the Y Chromosome Consortium worldwide panel of 76 diverse individuals
Variation of 52 new Y-STR loci in the Y Chromosome Consortium worldwide panel of 76 diverse individuals
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DOI：
10.1007/s00414-006-0124-8
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发表时间：
2007-03-01
影响因子：
2.1
通讯作者：
Tyler-Smith, Chris
中科院分区：
文献类型：
--
作者：
Lim, Si-Keun;Xue, Yali;Tyler-Smith, Chris
我们已经建立了16个小的2 - 4个位点的多重反应，以扩增52个最近描述的单拷贝简单的Y-STR，并在74个不同的男性和两名女性的全球面板中对这些位点进行分型。在该样本集中发现两个Y-STR通常是多拷贝的，并从研究中排除。在剩下的50个基因座中，有4个（DYS 481、DYS 570、DYS 576和DYS 643）表现出比常用基因座更高的差异性，并可能在法医学和人类学工作中提供更高的单倍型区分。10个位点偶见缺失等位基因、重复峰或中等大小等位基因。
We have established 16 small multiplex reactions of two-four loci to amplify 52 recently described single-copy simple Y-STRs and typed these loci in a worldwide panel of 74 diverse men and two women. Two Y-STRs were found to be commonly multicopy in this sample set and were excluded from the study. Of the remaining 50, four (DYS481, DYS570, DYS576 and DYS643) showed higher diversities than the commonly used loci and can potentially provide increased haplotype discrimination in both forensic and anthropological work. Ten loci showed occasional missing alleles, duplicated peaks or intermediate-sized alleles.