CEPHALIC PHASE OF INSULIN-SECRETION AND FOOD STIMULATION IN HUMANS - A NEW PERSPECTIVE
CEPHALIC PHASE OF INSULIN-SECRETION AND FOOD STIMULATION IN HUMANS - A NEW PERSPECTIVE
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DOI：
10.1152/ajpendo.1985.249.6.e639
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发表时间：
1985-12-01
影响因子：
--
通讯作者：
LEMAGNEN, J
中科院分区：
文献类型：
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作者：
BELLISLE, F;LOUISSYLVESTRE, J;LEMAGNEN, J
在人类受试者的午餐时间以1分钟的间隔测量胰岛素血症和胰岛素水平。当没有食物提供给未处理的受试者（n=4）时，发现胰岛素血症的周期性振荡（周期，12-20分钟;幅度，2.8-10.3 μ U/ml）。有人建议，这些自发振荡时，必须考虑到评价与食物刺激的头部接触的胰岛素反应，否则他们可能会构成一个来源的文物。四名受试者，然后提交了一系列的四个测试餐安排在1周的时间间隔。虽然他们的餐时胰岛素水平在进餐的前16分钟内与餐前值相当，但胰岛素血症通常表现出早期峰值（进餐后几分钟内），其幅度似乎与适口性条件相关。有证据表明，由头部刺激触发的胰岛素峰值是巴甫洛夫反射，其对测试情况形成条件反射。一个典型的神经内分泌反应消化挫折也被描述。结果进行了讨论的角度与动物作品，在神经内分泌事件对摄食行为的影响。
Insulinemia and glycemia were measured at a 1-min interval at the hour of a lunch meal in human subjects. When no food was presented to naive subjects (n=4), cyclic oscillations of insulinemia were found (period, 12-20 min; amplitude, 2.8-10.3 .mu.U/ml). It is proposed that these spontaneous oscillations must be taken into consideration when evaluating the insulin response on cephalic contact with food stimuli; they might otherwise constitute a source of artifacts. Four subjects were then submitted to a series of four test meals scheduled at a 1-wk interval. Although their prandial glycemia remained comparable with preprandial values for the first 16 min of the meals, insulinemia often exhibited early peaks (within a few min after meal onset) whose amplitude appeared related to palatability conditions. Evidence suggests that the insulin peaks triggered by cephalic stimulation are Pavlovian reflexes that become conditioned to the test situation. A typical neurendocrine response to alimentary frustration is also described. The results are discussed in perspective with animal works, in terms of the effects of neuroendocrine events on feeding behavior.