Hexavalent chromium is cytotoxic and genotoxic to American alligator cells.
Hexavalent chromium is cytotoxic and genotoxic to American alligator cells.
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DOI：
10.1016/j.aquatox.2015.12.004
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发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Wise JP Sr
中科院分区：
文献类型：
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作者：
Wise SS;Wise C;Xie H;Guillette LJ Jr;Zhu C;Wise JP Jr;Wise JP Sr
金属是水生生态系统中常见的污染物。随着全球气候变化，这些水平预计将上升，因为较低的PH值水平允许沉积物结合金属的释放。美洲扬子鳄是水生生态系统中的顶端捕食者，被认为是关键物种；因此，它是局部污染的合适监测器。一种日益受到关注的金属是六价铬(Cr(VI))。它存在于水环境中，是一种已知的人类致癌物质和生殖毒物。我们测定了铬(VI)对美洲鳄鳞状组织来源细胞的细胞毒性和遗传毒性。我们发现，微粒和可溶性铬(VI)对鳄鱼细胞均有细胞毒性和遗传毒性，且呈浓度依赖关系。这些数据表明，鳄鱼可以被用作评估环境铬(VI)污染以及其他令人关注的金属的影响的模型。
Metals are a common pollutant in the aquatic ecosystem. With global climate change, these levels are anticipated to rise as lower pH levels allow sediment bound metals to be released. The American alligator (Alligator mississippiensis) is an apex predator in the aquatic ecosystem and is considered a keystone species; as such it serves as a suitable monitor for localized pollution. One metal of increasing concern is hexavalent chromium (Cr(VI)). It is present in the aquatic environment and is a known human carcinogen and reproductive toxicant. We measured the cytotoxicity and genotoxicity of Cr(VI) in American alligator cells derived from scute tissue. We found that particulate and soluble Cr(VI) are both cytotoxic and genotoxic to alligator cells in a concentration-dependent manner. These data suggest that alligators may be used as a model for assessing the effects of environmental Cr(VI) contamination as well as for other metals of concern.