Evolution of Escherichia coli during growth in a constant environment.
Evolution of Escherichia coli during growth in a constant environment.
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DOI：
10.1093/genetics/116.3.349
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发表时间：
1987-07
期刊：
影响因子：
3.3
通讯作者：
R. Helling;Christopher N. Vargas;Julian Adams
中科院分区：
文献类型：
--
作者：
R. Helling;Christopher N. Vargas;Julian Adams
大肠杆菌的人口，开始与一个单一的克隆，并保持了很长一段时间的葡萄糖限制连续培养，开发了广泛的多态性。在一个种群中，经过765代的研究，确定了两种多数和两种少数类型。从分离的菌株中重新建立稳定的混合群体。参与这种多态性的发展的因素包括在最大比生长速率和葡萄糖的运输，和排泄的代谢产物由少数克隆利用的一些克隆的差异。
Populations of Escherichia coli, initiated with a single clone and maintained for long periods in glucose-limited continuous culture, developed extensive polymorphisms. In one population, examined after 765 generations, two majority and two minority types were identified. Stable mixed populations were reestablished from the isolated strains. Factors involved in the development of this polymorphism included differences in the maximum specific growth rate and in the transport of glucose, and excretion of metabolites by some clones which were utilized by minority clones.