Effects of ethyl alcohol administration to THA rat dams during their gestation period on learning behavior and on levels of monoamines and metabolites in the brain of pups after birth.
Effects of ethyl alcohol administration to THA rat dams during their gestation period on learning behavior and on levels of monoamines and metabolites in the brain of pups after birth.
复制标题
妊娠期 THA 母鼠注射乙醇对学习行为以及出生后幼仔大脑中单胺和代谢物水平的影响。
DOI：
10.1111/j.1530-0277.1996.tb01798.x
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Isao Okazaki
中科院分区：
文献类型：
--
作者：
H. Furuya;Hiroyuki Aikawa;Takahiko Yoshida;Isao Okazaki
慢性酒精中毒母亲所生的儿童表现出行为致畸作用比形态畸形更频繁。为了研究可能的机制和评估母体酒精剂量水平诱导行为功能障碍，我们给怀孕的东海高回避（THA）大鼠0，5，10，和20%的乙醇（EtOH）作为饮用水在妊娠期。我们评估了由酒精管理的母鼠所生的幼崽的脑功能。采用Sidman回避行为试验、全脑单胺类（去甲肾上腺素、多巴胺和5-羟色胺）及其代谢产物（3，4-二羟基苯乙酸、高香草酸和5-羟基吲哚乙酸）的水平，观察神经行为和神经化学效应。EtOH暴露的THA后代表现出较高的产前和产后死亡率、生长缺陷和脑重量减轻。与Wistar大鼠的相同条件实验结果相比，THA大鼠可能比Wistar大鼠对子宫内EtOH暴露的影响具有更高的易感性。EtOH暴露的THA幼仔表现出回避操作性学习的缺陷，而Wistar大鼠未表现出这种缺陷。我们还观察到所有单胺的水平增加，这被认为是与学习的缺陷，降低水平的3，4-二羟基苯基乙酸和高香草酸，和不变的水平5-羟基吲哚乙酸的母鼠管理10和20%乙醇的幼崽。然而，在5%乙醇给药母鼠的幼仔中显示了单胺及其代谢产物的相反变化。
Children born from chronic alcoholic mothers have shown behavioral teratogenic effects more frequently than morphological malformations. To investigate the possible mechanisms and evaluate maternal alcohol dosage levels to induce behavioral dysfunctions, we gave pregnant Tokai High Avoider (THA) rats 0, 5, 10, and 20% ethanol (EtOH) as drinking water during the gestation period. We evaluated the brain function of pups born of alcohol-administered dams. Sidman avoidance behavior test and the levels of monoamines (nor-adrenalin, dopamine, and serotonin) and metabolites (3, 4-dihydroxyphenyl acetic acid, homovanillic acid, and 5-hydroxyindole acetic acid) in whole brain were examined for neurobehavioral and neurochemical effects. EtOH-exposed THA offsprings showed high pre- and postnatal mortality, growth deficits, and brain weight reductions. Compared with the results of the same conditioning experiment using Wistar rats, the THA rat may have higher susceptibility to the effects of in utero EtOH exposure than Wistar rats. EtOH-exposed THA pups exhibited deficits in avoidance operant learning that were not shown in Wistar rats. We also observed the increased levels of all monoamines that were assumed to be related with the deficit of learning, the decreased levels of 3, 4-dihydroxyphenyl acetic acid and homovanillic acid, and the unchanged levels of 5-hydroxyindole acetic acid in pups from dams administered 10 and 20% EtOH. However, contrary alteration of monoamines and their metabolites were shown in pups from 5% EtOH-administered dams.
流质饮食中产前乙醇暴露对大鼠后代发育和行为影响的寄养/交叉寄养分析。
影响因子：
2.9
作者：
Vorhees,CV
通讯作者：
Vorhees,CV
母亲年龄是决定产前暴露于乙醇的大鼠的生殖和行为结果的一个因素。
影响因子：
2.9
作者：
Vorhees,CV
通讯作者：
Vorhees,CV
遗传对因发育接触酒精而引起的大脑生长受限的影响。
影响因子：
3.4
作者：
Goodlett,CR;Gilliam,DM;Nichols,JM;West,JR
通讯作者：
West,JR