Analysis of etiology, chromosome and prognosis for small left heart system development in 69 fetuses
Analysis of etiology, chromosome and prognosis for small left heart system development in 69 fetuses
复制标题
69例胎儿左心小系统发育的病因、染色体及预后分析
DOI：
10.3109/14767058.2015.1007037
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发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Huang Lei
中科院分区：
文献类型：
--
作者：
Liu Lin;He Yihua;Li Zhian;Cui Cunying;Zhang Lianzhong;Li Tao;Liao Shixiu;Fan Taibing;Peng Bangtian;Yao Huimei;Huang Lei
摘要目的：分析胎儿小左心系统发育的相关因素，为评估胎儿小左心系统发育的预后提供依据。方法：对3859例孕妇进行胎儿超声心动图检查，并对其中69例胎儿进行小左心系统发育检查。对69例胎儿产前、产后超声心动图、产后心脏外科治疗、染色体及引产后尸检资料进行分析。结果：除失访1320例外，资料完整者2539例。在2539例病例中，有69例胎儿发现了小左心系统发育。69例胎儿中，左心发育不良综合征12例，卵圆孔早闭20例，完全性肺静脉异位引流13例，肺静脉腔闭锁2例，主动脉缩窄或中断21例，右肺发育不良1例。69例胎儿中7例染色体异常。结论：引起小左心系统发育的病因是多方面的。合并左心发育不良综合征、肺静脉腔闭锁、肺发育不良、其他畸形或/和染色体异常的胎儿预后差。胎儿超声心动图结合染色体检查可为小左心系统发育的诊断和预后评估提供重要依据。
Abstract Objective: To provide a basis for evaluating the prognosis of small left heart system development in fetuses, we analyzed its related factors. Methods: The fetal echocardiogram was performed in 3859 pregnant women, and then small left heart system development was identified in 69 fetuses. The data of prenatal and postnatal echocardiograms, postnatal cardiac surgical treatment, chromosome and autopsy after induced labor were analyzed in the 69 fetuses. Results: Except 1320 cases losing follow-up, 2539 cases had complete data. Among the 2539 cases, small left heart system development was identified in 69 fetuses. Of the 69 fetuses, 12 had hypoplastic left heart syndrome, 20 premature closure of foramen ovale, 13 total anomalous pulmonary venous drainage, 2 common pulmonary vein lumen atresia, 21 aortic coarctation or interruption and 1 right pulmonary hypoplasia. Among the 69 fetuses, chromosome abnormality was found in 7. Conclusion: There are many etiological factors causing small left heart system development. The prognosis is poor in the fetuses with hypoplastic left heart syndrome, common pulmonary vein lumen atresia, pulmonary hypoplasia, other malformations or/and chromosome abnormality. Fetal echocardiography combined with chromosome examination can provide important bases for making diagnosis and evaluating the prognosis regarding small left heart system development.
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影响因子：
2.1
作者：
P. Vergani
通讯作者：
P. Vergani
影响因子：
6
作者：
Tweddell, James S.;Sleeper, Lynn A.;Ohye, Richard G.;Williams, Ismee A.;Mahony, Lynn;Pizarro, Christian;Pemberton, Victoria L.;Frommelt, Peter C.;Bradley, Scott M.;Cnota, James F.;Hirsch, Jennifer;Kirshbom, Paul M.;Li, Jennifer S.;Pike, Nancy;Puchalski, Michael;Ravishankar, Chitra;Jacobs, Jeffrey P.;Laussen, Peter C.;McCrindle, Brian W.
通讯作者：
McCrindle, Brian W.
影响因子：
1.7
作者：
J. Tibballs;Y. Kawahira;Bradley Carter;S. Donath;C. Brizard;J. Wilkinson
通讯作者：
J. Tibballs;Y. Kawahira;Bradley Carter;S. Donath;C. Brizard;J. Wilkinson
影响因子：
2.8
作者：
BERRY, TE;BHARATI, S;PAUL, MH
通讯作者：
PAUL, MH
DOI：
10.1053/j.pcsu.2013.01.001
发表时间：
2013
期刊：
Seminars in thoracic and cardiovascular surgery. Pediatric cardiac surgery annual
影响因子：
--
作者：
E. Bacha
通讯作者：
E. Bacha