Growth and somatomedin-C responses to growth hormone in dwarfed children.
Growth and somatomedin-C responses to growth hormone in dwarfed children.
复制标题
侏儒儿童的生长和生长调节素-C 对生长激素的反应。
DOI：
10.1016/s0022-3476(81)80008-x
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Peake,GT
中科院分区：
文献类型：
--
作者：
Hayek,A;Peake,GT
研究对象为19名身材矮小的儿童。他们的年龄Sm-c值普遍异常低，每个人都接受了为期10天的外源性生长激素治疗。根据他们的内源性GH浓度和对GH治疗的反应，根据Sm-C和身高增量，他们被分为三组。I组包括生长激素不足患者，他们对刺激的生长激素反应迟钝，但通过正常化Sm-C浓度和生长速度对治疗有反应。II组患者对刺激均有正常的GH反应，但对外源性GH的反应与GH缺陷组相似。在内源性GH释放正常的III组中，Sm-C值和生长率对GH的反应没有增加。第二组患者可能代表了生物不活跃但免疫反应活跃的生长激素儿童，而第三组儿童是Laron型侏儒症的例子。因此，短期外源性GH治疗的Sm-C和生长增量反应可能更准确地识别将从长期GH治疗中受益的儿童，而不是血浆GH对刺激刺激的反应。
Nineteen children were studied because of short stature. They had in common abnormally low Sm-Cvalues for age, and each received a ten-day course of exogenous GH therapy. Based on their endogenous GH concentrations and the response to GH therapy, in terms of Sm-C and height increments, they were classified into three groups. Group I included patients with GH insufficiency who had blunted GH responses to stimulation, but responded to therapy by normalizing the Sm-C concentration and velocity of growth. Group II patients all had normal GH responses to stimulation, but their responses to exogenous GH were similar to those observed in the GH deficient subjects. In the two children in Group III who had normal release of endogenous GH, Sm-C values and growth rate did not increase in response to GH. Group II patients may represent children with biologically inactive but immunoreactive GH, whereas the children in Group III are examples of the Laron type of dwarfism. Thus, rather than the plasma GH response to provocative stimuli, the Sm-C and growth increment responses to short-term exogenous GH therapy may more precisely identify children that will benefit from long-term GH therapy.