Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats
Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats
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DOI：
10.1016/j.neurobiolaging.2007.04.028
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发表时间：
2008-12-01
影响因子：
4.2
通讯作者：
Wenk, Gary L.
中科院分区：
文献类型：
--
作者：
Marchalant, Yannick;Cerbai, Francesca;Wenk, Gary L.
在正常衰老过程中，激活的小胶质细胞数量增加。内源性大麻素受体的刺激可以减少长期注入脂多糖（LPS）的幼鼠的活化的小胶质细胞的数量，特别是在海马中。在当前的研究中，我们证明，通过给予WIN-55212-2（2 mg/kg/天）刺激内源性大麻素受体可以减少老年大鼠海马中活化小胶质细胞的数量，并减轻水池任务中的空间记忆障碍。我们的结果表明，WIN-55212-2的作用不依赖于对microgolia或星形胶质细胞的直接作用，而是依赖于对神经元大麻素受体的刺激。衰老显着降低大麻素1型受体结合，但对大麻素受体蛋白水平没有影响。大麻素受体的刺激可以在与脑炎症相关的a-c相关疾病中提供临床益处，例如阿尔茨海默病。0 2007 Elsevier Inc. All rights reserved.
The number of activated microglia increase during normal aging. stimulation of endocannabinoid receptors can reduce the number of activated microglia, particularly in the hippocampus, of young rats infused chronically with lipopolysaccharide (LPS). In the current study we demonstrate that endocannabinoid receptor stimulation by administration of WIN-55212-2 (2 mg/kg day) can reduce the number of activated microglia in hippocampus of aged rats and attenuate the spatial memory impairment in the water pool task. Our results suggest that the action of WIN-55212-2 does not depend upon a direct effect upon microgolia or astrocytes hut is dependent upon stimulation of neuronal cannabinoid receptors. Aging significantly reduced cannabinoid type 1 receptor binding but had no effect on cannabinoid receptor protein levels. Stimulation of cannabinoid receptors may provide clinical benefits in a-c-related diseases that are associated with brain inflammation, Such as Alzheimer's disease. 0 2007 Elsevier Inc. All rights reserved.