BAR domain proteins-a linkage between cellular membranes, signaling pathways, and the actin cytoskeleton.
BAR domain proteins-a linkage between cellular membranes, signaling pathways, and the actin cytoskeleton.
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DOI：
10.1007/s12551-018-0467-7
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发表时间：
2018-12-01
影响因子：
--
通讯作者：
Dominguez, Roberto
中科院分区：
文献类型：
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作者：
Carman, Peter J;Dominguez, Roberto
肌动蛋白丝组装通常与细胞膜结合发生。大量的蛋白质位于肌动蛋白网络和膜之间的界面处，发挥着不同的作用，如启动肌动蛋白聚合，调节膜曲率和信号传导。Bin/Amphiphysin/Rvs（BAR）结构域蛋白已涉及所有这些功能。BAR结构域家族的蛋白质包括一组不同的多功能效应子，其特征在于它们的模块化结构。除了也介导反平行二聚化的膜曲率感应/诱导BAR结构域模块之外，大多数还含有涉及蛋白质-蛋白质和/或蛋白质-膜相互作用的辅助结构域，包括SH 3、PX、PH、RhoGEF和RhoGAP结构域。BAR域本身的形状各不相同，导致三个主要的子族：经典的新月形BAR，更多延伸和更少弯曲的F-BAR，以及反曲率I-BAR子族。该家族的大多数成员参与需要肌动蛋白细胞骨架动态重塑的细胞功能，如内吞作用、细胞器运输、细胞运动和肌细胞中的T-小管生物发生。在这里，我们回顾了哺乳动物BAR结构域蛋白的结构和功能，以及它们与肌动蛋白细胞骨架相互连接的许多方式。
Actin filament assembly typically occurs in association with cellular membranes. A large number of proteins sit at the interface between actin networks and membranes, playing diverse roles such as initiation of actin polymerization, modulation of membrane curvature, and signaling. Bin/Amphiphysin/Rvs (BAR) domain proteins have been implicated in all of these functions. The BAR domain family of proteins comprises a diverse group of multi-functional effectors, characterized by their modular architecture. In addition to the membrane-curvature sensing/inducing BAR domain module, which also mediates antiparallel dimerization, most contain auxiliary domains implicated in protein-protein and/or protein-membrane interactions, including SH3, PX, PH, RhoGEF, and RhoGAP domains. The shape of the BAR domain itself varies, resulting in three major subfamilies: the classical crescent-shaped BAR, the more extended and less curved F-BAR, and the inverse curvature I-BAR subfamilies. Most members of this family have been implicated in cellular functions that require dynamic remodeling of the actin cytoskeleton, such as endocytosis, organelle trafficking, cell motility, and T-tubule biogenesis in muscle cells. Here, we review the structure and function of mammalian BAR domain proteins and the many ways in which they are interconnected with the actin cytoskeleton.