Erratum: The Cardamine hirsuta genome offers insight into the evolution of morphological diversity.
Erratum: The Cardamine hirsuta genome offers insight into the evolution of morphological diversity.
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DOI：
10.1038/nplants.2016.189
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发表时间：
2016-11-07
期刊：
影响因子：
18
通讯作者：
Tsiantis, Miltos
中科院分区：
文献类型：
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作者：
Gan, Xiangchao;Hay, Angela;Kwantes, Michiel;Haberer, Georg;Hallab, Asis;Ioio, Raffaele Dello;Hofhuis, Hugo;Pieper, Bjorn;Cartolano, Maria;Neumann, Ulla;Nikolov, Lachezar A;Song, Baoxing;Hajheidari, Mohsen;Briskine, Roman;Kougioumoutzi, Evangelia;Vlad, Daniela;Broholm, Suvi;Hein, Jotun;Meksem, Khalid;Lightfoot, David;Shimizu, Kentaro K;Shimizu-Inatsugi, Rie;Imprialou, Martha;Kudrna, David;Wing, Rod;Sato, Shusei;Huijser, Peter;Filatov, Dmitry;X Mayer, Klaus F;Mott, Richard;Tsiantis, Miltos
发现基因型和表型变异之间的因果关系是进化生物学、人类遗传学和植物育种的一个关键焦点。为了确定性状多样性的全基因组模式，我们组装了一个高质量的小豆蔻（Cardamine hirsuta）参考基因组，小豆蔻是模式植物拟南芥（Arabidopsis thaliana）的近亲。我们将比较基因组和转录组分析与现有的实验工具相结合，研究毛毛草的基因功能和表型多样化。我们的发现突出了转录因子和串联基因复制在形态进化中的普遍作用。我们确定了转录调控因子PLETHORA5/7在毛毛草（C. hirsuta）爆炸种子荚中形成叶片多样性和串联基因重复与差异基因表达之间的特殊作用。我们的工作强调了比较方法在遗传易感物种中的价值，以了解进化变化的遗传基础。
Finding causal relationships between genotypic and phenotypic variation is a key focus of evolutionary biology, human genetics and plant breeding. To identify genome-wide patterns underlying trait diversity, we assembled a high-quality reference genome of Cardamine hirsuta, a close relative of the model plant Arabidopsis thaliana. We combined comparative genome and transcriptome analyses with the experimental tools available in C. hirsuta to investigate gene function and phenotypic diversification. Our findings highlight the prevalent role of transcription factors and tandem gene duplications in morphological evolution. We identified a specific role for the transcriptional regulators PLETHORA5/7 in shaping leaf diversity and link tandem gene duplication with differential gene expression in the explosive seed pod of C. hirsuta. Our work highlights the value of comparative approaches in genetically tractable species to understand the genetic basis for evolutionary change.