Nonequilibrium membrane fluctuations driven by active proteins
Nonequilibrium membrane fluctuations driven by active proteins
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DOI：
10.1063/1.2166383
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发表时间：
2006-02-21
影响因子：
4.4
通讯作者：
Brown, FLH
中科院分区：
文献类型：
--
作者：
Lin, LCL;Gov, N;Brown, FLH
我们扩展了一个由活性（三磷酸腺苷依赖或光收集）膜蛋白驱动的非热膜波动模型[N]。政府、phy。[j].科学通报，2004(5)。目前的模型解释了这样一个事实，即蛋白质可以横向扩散穿过膜表面，并且单个蛋白质预计会优先在一个正常方向上施加力（由于它们在双层内的方向）。这些效应的加入改变了波动幅度随系统大小的比例。此外，理论论证和动态模拟都表明，在某些情况下，波动幅度的概率分布预计是非高斯分布（与热系统相反）。
We extend a model for nonthermal membrane undulations driven by active (adenosine triphosphate-dependent or light-harvesting) membrane proteins [N. Gov, Phys. Rev. Lett. 93, 268104 (2004)]. The present model accounts for the fact that proteins can diffuse laterally across the membrane surface and that individual proteins are expected to exert forces preferentially in one normal direction over the other (due to their orientation within the bilayer). The addition of these effects alters the scaling of fluctuation amplitudes with system size. Additionally, theoretical arguments and dynamic simulations both suggest that, in certain regimes, the probability distribution of fluctuation amplitudes is expected to be non-Gaussian (in contrast to thermal systems).