Clinical and laboratory parameters in predicting chronic urticaria duration: a prospective study of 139 patients
Clinical and laboratory parameters in predicting chronic urticaria duration: a prospective study of 139 patients
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DOI：
10.1111/j.1398-9995.2004.00473.x
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发表时间：
2004-08-01
期刊：
影响因子：
12.4
通讯作者：
Panasoff, J
中科院分区：
文献类型：
--
作者：
Toubi, E;Kessel, A;Panasoff, J
背景资料：尽管慢性荨麻疹（CU）具有致残性，但对疾病的持续时间或采用积极治疗方案（如环孢素A）的疗效知之甚少。目的：本研究的目的是评估血管性水肿、自体血清试验、抗甲状腺抗体和总IgE等参数是否可以预测CU的持续时间和严重程度。对139例CU患者进行了为期5年的前瞻性随访，以了解疾病持续时间、严重程度和血管性水肿的存在。还调查了这些临床参数和随后的检测自体血清试验，抗甲状腺抗体，总IgE.Results：CU持续超过1年的情况下，超过70%，在14%，5年后仍然存在之间的关联。40%的患者在CU过程中同时存在或出现血管性水肿，并与疾病持续时间相关。自体血清试验和抗甲状腺抗体阳性的患者分别为28和12%，与正常人相比，P = 0.001。CU持续时间与存在的自体血清测试和抗甲状腺抗体;然而，自体血清测试，而不是抗甲状腺抗体被发现与CU severity.Conclusion：我们首次证明，CU持续时间与临床参数，如严重程度和血管性水肿，并与实验室参数，如自体血清测试和抗甲状腺抗体。预测CU持续时间的能力可能有助于决定是否早期开始环孢菌素A治疗，以降低疾病的严重程度和持续时间。
Background: Despite the disabling nature of chronic urticaria (CU), little is known about the disease's duration or the efficacy of adopting aggressive therapeutic regimens such as cyclosporine A.Objectives: The aim of this study was to evaluate whether parameters such as angioedema, autologous serum test, anti-thyroid antibodies, and total IgE could predict both CU duration and severity.Patients and methods: One hundred and thirty-nine patients suffering from CU were prospectively followed over a 5-year period for disease duration, severity and the presence of angioedema. Also investigated was the association between these clinical parameters and the subsequent detection of autologous serum test, anti-thyroid antibodies, and total IgE.Results: CU lasted over 1 year in more than 70% of cases and in 14% it still existed after 5 years. Angioedema co-existed or appeared during the course of CU in 40% of patients and was associated with disease duration. Autologous serum test and anti-thyroid antibodies were found positive in 28 and 12% of patients, respectively, compared to none of normal individuals, P = 0.001. CU duration was associated with the presence of both autologous serum test and anti-thyroid antibodies; however, autologous serum test and not anti-thyroid antibodies was found in association with CU severity.Conclusion: We demonstrate for the first time that CU duration is associated with clinical parameters such as severity and angioedema, and with laboratory parameters such as autologous serum test and anti-thyroid antibodies. The ability to predict CU duration may facilitate decisions regarding the possible early initiation of cyclosporine A as a means by which to reduce disease severity and duration.