Regulation of inflammation by lipid mediators in oral diseases.
Regulation of inflammation by lipid mediators in oral diseases.
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口腔疾病中脂质介质对炎症的调节。
DOI：
10.1111/odi.12544
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发表时间：
2017-07
期刊：
影响因子：
3.8
通讯作者：
Baker OJ
中科院分区：
文献类型：
--
作者：
Sommakia S;Baker OJ
炎症的脂质介质（Lipid mediators，LM）是一类由ω-3和ω-6脂肪酸衍生的化合物，在调节炎症反应中起着广泛的作用。一些LM具有促炎特性，而另一些具有促消退特性，并且从促炎到促消退的类别转换对于组织稳态是至关重要的。在这篇文章中，我们回顾了LM的主要类别，重点是它们的生物合成和信号通路，以及它们在全身，特别是口腔健康和疾病中的作用。我们讨论了这些LM在各种体液中的检测，重点是诊断和治疗应用。我们还提供了健康对照组中唾液LM水平的性别相关差异数据，从而提出了炎症性疾病（特别是干燥综合征）病因学的假设。最后，我们列举了开放的研究领域，进一步调查LM可能会导致治疗和诊断的进步。
Lipid mediators (LM) of inflammation are a class of compounds derived from ω-3 and ω-6 fatty acids that play a wide role in modulating inflammatory responses. Some LM possess pro-inflammatory properties, while others possess pro-resolving characteristics, and the class switch from pro-inflammatory to pro-resolving is crucial for tissue homeostasis. In this article, we review the major classes of LM, focusing on their biosynthesis and signaling pathways, and their role in systemic and, especially, oral health and disease. We discuss the detection of these LM in various body fluids, focusing on diagnostic and therapeutic applications. We also present data showing gender-related differences in salivary LM levels in healthy controls, leading to a hypothesis on the etiology of inflammatory diseases, particularly, Sjögren’s Syndrome. We conclude by enumerating open areas of research where further investigation of LM is likely to result in therapeutic and diagnostic advances.