Environmental control of nucleophilic catalysis in water
Environmental control of nucleophilic catalysis in water
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DOI：
10.1039/c3cc49593k
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发表时间：
2014-01-01
影响因子：
4.9
通讯作者：
Zhao, Yan
中科院分区：
文献类型：
--
作者：
Chadha, Geetika;Zhao, Yan
吡啶基在酯/磷酸酯水解中的亲核催化作用受到催化剂周围微环境疏水性的调节。催化效率提高了数千倍或数万倍，并且活性保持在远低于吡啶基的pK（a）。
The nucleophilic catalysis by a pyridyl group in ester/phosphate ester hydrolysis was modulated by the microenvironmental hydrophobicity around the catalyst. The catalytic efficiency was enhanced thousands or tens of thousands of times and the activity was maintained well below the pK(a) of the pyridyl group.