Repurposing a pore: highly conserved perforin-like proteins with alternative mechanisms.
Repurposing a pore: highly conserved perforin-like proteins with alternative mechanisms.
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DOI：
10.1098/rstb.2016.0212
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发表时间：
2017-08-05
期刊：
影响因子：
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通讯作者：
Gilbert RJC
中科院分区：
文献类型：
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作者：
Ni T;Gilbert RJC
孔形成蛋白在病原攻击和免疫防御中起重要作用。膜攻击复合物/穿孔素（MACPF）同系物与胆固醇依赖性细胞溶解素是这类蛋白中最大的家族。在这篇综述中，我们首先简要地描述了MACPF蛋白的结构，概述了它们共同的孔形成机制。我们随后讨论了一些可能涉及孔形成或其他膜重塑过程的MACPF蛋白的例子。最后，我们将重点放在星形胶质蛋白和骨形态发生蛋白以及维甲酸诱导的神经特异性蛋白上，这些高度保守的MACPF家族成员参与发育过程，迄今尚未得到很好的研究或观察到形成孔，数据表明它们可能通过其他机制起作用。本文是专题“膜孔：从结构和组装到医学和技术”的一部分。
Pore-forming proteins play critical roles in pathogenic attack and immunological defence. The membrane attack complex/perforin (MACPF) group of homologues represents, with cholesterol-dependent cytolysins, the largest family of such proteins. In this review, we begin by describing briefly the structure of MACPF proteins, outlining their common mechanism of pore formation. We subsequently discuss some examples of MACPF proteins likely implicated in pore formation or other membrane-remodelling processes. Finally, we focus on astrotactin and bone morphogenetic protein and retinoic acid-induced neural-specific proteins, highly conserved MACPF family members involved in developmental processes, which have not been well studied to date or observed to form a pore—and which data suggest may act by alternative mechanisms. This article is part of the themed issue ‘Membrane pores: from structure and assembly, to medicine and technology’.