Genetic maternal effects on cleft lip frequency in A/J and CL/Fr mice.
Genetic maternal effects on cleft lip frequency in A/J and CL/Fr mice.
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母体遗传对 A/J 和 CL/Fr 小鼠唇裂频率的影响。
DOI：
10.1002/tera.1420210206
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
F. Fraser
中科院分区：
文献类型：
--
作者：
D. Juriloff;F. Fraser
两个相关品系的小鼠，A/J和CL/Fr，在足月胎儿产生自发性唇裂的频率上不同：10%对25%。为了检查这种差异的遗传基础的性质，进行了不同品系之间的杂交。结果表明，导致品系差异的是母亲体内的基因，而不是胚胎中的基因，它们可能对CL(P)胚胎的存活产生影响，而不是发生。A/J株的等位基因对CL/Fr株的等位基因占优势，单基因座差异可以解释这一数据。当多基因加性阈值模型应用于人类数据时，应考虑到遗传母体效应对具有显性的小鼠CL(P)频率的重要性。这两种效应在模型中都是不允许的，然而，如果这些特征在物种之间是同源的，这些效应很可能出现在人类身上，就像在老鼠身上一样。
Two related strains of mice, A/J and CL/Fr, differ in the frequency of spontaneous cleft lip produced in term fetuses: 10% versus 25%. In order to examine the nature of the genetic basis for this difference, various crosses between the strains were made. The results indicated that genes acting in the mothers, rather than in the embryos, caused the strain difference, and that their effect may be on CL(P) embryo survival rather than occurrence. The A/J strain alleles were dominant to those of CL/Fr, and a one-locus difference can explain the data. The importance of genetic maternal effects on CL(P) frequency in mice, with dominance, should be borne in mind when the polygenic, additive threshold model is applied to human data. Neither effect is allowed within the model, yet if the traits are homologous between species, these effects may well be present in man as in the mouse.