The Anti-Arthritis Effect of Cinnamaldehyde on Adjuvant Arthritis Rats
The Anti-Arthritis Effect of Cinnamaldehyde on Adjuvant Arthritis Rats
复制标题
肉桂醛对佐剂性关节炎大鼠的抗关节炎作用
DOI：
--
复制
发表时间：
2022-03
影响因子：
1.3
通讯作者：
Xiaoqin Chu
中科院分区：
文献类型：
--
作者：
Baoqi Dong;jingbao Chen;Wenqing Wu;Xiaoqin Chu
背景和目的：从中药肉桂中分离得到挥发油的主要成分肉桂醛。肉桂醛具有抗病毒、抗糖尿病、抗炎、抗癌和抗血栓形成等多种药理和生物活性。本研究旨在评价肉桂70%水乙醇提取物在慢性炎症模型中的抗关节炎作用，并揭示其分子机制。材料与方法：通过将完全弗氏佐剂（CFA）注射到Sprague-Dawley大鼠的右后爪的足底来诱导大鼠中的佐剂性关节炎。观察大鼠足肿胀度、体重、关节炎指数、胸腺指数和脾脏指数. ELISA法检测血清TNF-α、IL-1、IL-6、IL-10和PGE2水平。使用苏木精和伊红（H和E）测量关节组织的组织病理学转化。结果如下：肉桂可显著减轻CFA所致小鼠体重下降，抑制关节炎指数和足爪肿胀，降低胸腺指数和脾脏指数。肉桂醇还能显著抑制CFA诱导的大鼠血清TNF-α、IL-1、IL-6和PGE_2的过度产生，并能显著增加血清IL-10的产生。组织学检查表明，肉桂酸可减轻滑膜增生、骨和软骨损伤及炎性细胞浸润。结论：肉桂醛对CFA诱导的大鼠关节炎具有潜在的保护作用。
Background and Objective: Cinnamaldehyde, the main component of volatile oil was isolated from the traditional Chinese herb medicinal Cinnamomum cassia. A variety of pharmacological and biological activities of cinnamaldehyde have been fully demonstrated, such as antiviral, antidiabetic, anti-inflammatory, anticancer and antithrombotic effects. The present study aimed to evaluate the anti-arthritic effects of a 70% aqueous ethanol extract of the Cinnamomum cassia in a chronic inflammatory model and reveal the underlying molecular mechanism. Materials and Methods: Induction of adjuvant arthritis in rats was by injection of Complete Freund's Adjuvant (CFA) into the plantar of the right hind paw of Sprague-Dawley rats. Paw swelling, body weight, arthritis index, thymus index and spleen index were and evaluated. Examine the level of TNF-α, IL-1, IL-6, IL-10 and PGE2 in sera by using ELISA. Measure the histopathological conversions in joint tissues by using Hematoxylin and Eosin (H and E). Results: Cinnamaldehydesignificantly relieved body weight loss, refrained arthritis index and paw swelling, decreased the thymus index and spleen index induced by CFA. Furthermore, cinnamaldehydesignificantly suppressed the overproduction of and serum TNF-α, IL-1, IL-6 and PGE2 and increased serum IL-10 production in and CFA-induced rats. Histopathological examination indicated that cinnamaldehydeattenuated synovial hyperplasia, bone and cartilage damage and inflammatory cell infiltration. Conclusion: These results suggest that cinnamaldehyde has the potential protective effect against CFA-induced arthritis in rats.