Metabolic Phenotypes, Dependencies, and Adaptation in Lung Cancer.
Metabolic Phenotypes, Dependencies, and Adaptation in Lung Cancer.
复制标题
肺癌的代谢表型、依赖性和适应。
DOI：
10.1101/cshperspect.a037838
复制
发表时间：
2021
影响因子：
5.4
通讯作者：
Shackelford,DavidB
中科院分区：
文献类型：
--
作者：
DeNicola,GinaM;Shackelford,DavidB
Lung cancer is a heterogeneous disease that is subdivided into histopathological subtypes with distinct behaviors. Each subtype is characterized by distinct features and molecular alterations that influence tumor metabolism. Alterations in tumor metabolism can be exploited by imaging modalities that use metabolite tracers for the detection and characterization of tumors. Microenvironmental factors, including nutrient and oxygen availability and the presence of stromal cells, are a critical influence on tumor metabolism. Recent technological advances facilitate the direct evaluation of metabolic alterations in patient tumors in this complex microenvironment. In addition, molecular alterations directly influence tumor cell metabolism and metabolic dependencies that influence response to therapy. Current therapeutic approaches to target tumor metabolism are currently being developed and translated into the clinic for patient therapy.
