Prevalence of human cosaviruses in Tunisia, North Africa
Prevalence of human cosaviruses in Tunisia, North Africa
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北非突尼斯人类冠状病毒的流行情况
DOI：
10.1002/jmv.24076
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发表时间：
2015
影响因子：
12.7
通讯作者：
H. Triki
中科院分区：
文献类型：
--
作者：
D. Rezig;E. B. Farhat;H. Touzi;Z. Meddeb;A. Salah;H. Triki
最近从巴基斯坦和阿富汗的急性弛缓性麻痹（AFP）儿童和健康儿童的粪便中分离出一种新的小核糖核酸病毒，称为人类Cosavirus（HCoSV）。此后也与其他国家的患者隔离。目前已鉴定出五个物种，形成小核糖核酸病毒科中的一个新属。本研究报告了 2011 年至 2012 年间作为突尼斯国家脊髓灰质炎病毒监测计划的一部分从 AFP 患者及其接触者中的健康个体收集的粪便标本中检测到 HCoSV。通过 RT-PCR 对基因组 5' 非编码区的 194 份粪便样本进行了研究。共有 64 份样本 (33%) 检测出 HCoSV 呈阳性。在 36 名患有神经系统综合征的病例及其 28 名健康接触者中发现了 HCoSV 阳性标本。 HCoSV 感染率最高（62.5%）发生在 6 岁以下儿童中。粪便标本的采样日期表明，HCoSV 感染随着时间的推移有规律地发生。此外，粪便样本的采样来源显示，突尼斯从北部到南部的几乎所有省份都检测到了 HCoSV 感染。这项研究是北非地区 HCoSV 患病率的第一份报告。它有助于更好地了解这些病毒的地理分布和流行病学。 J. Med。病毒。 87:940–943，2015 年。© 2015 Wiley periodicals, Inc.
A new picornavirus, named human Cosavirus (HCoSV) was isolated recently from stools of children with acute flaccid paralysis (AFP) and healthy children in Pakistan and Afghanistan. Since then, it was also isolated from patients from other countries. Five species are presently identified forming a new genus in the Picornaviridae family. This study reports the detection of HCoSV in stool specimens collected as part of the National Poliovirus surveillance Program in Tunisia, between 2011 and 2012, from patients with AFP and healthy individuals among their contacts. One hundred and ninety four stool samples were investigated by RT‐PCR in the 5' non‐coding region of the genome. A total of 64 specimens (33%) tested positive for HCoSV. HCoSV positive specimens were found in 36 cases with neurological syndromes and 28 of their healthy contacts. The highest rate of HCoSV infection (62.5%) occurred in children younger than 6 years of age. The sampling date of stool specimens suggested that HCoSV infection occurred regularly over time. Also, the sampling origin of stool specimen showed that HCoSV infection was detected in almost all the governorates of Tunisia from the North to the South of the country. This study is the first report of HCoSV prevalence in the North African region. It contributes to a better knowledge on the geographic distribution and the epidemiology of these viruses. J. Med. Virol. 87:940–943, 2015. © 2015 Wiley Periodicals, Inc.