Influence of Surface Chemistry on the Release of an Antibacterial Drug from Nanostructured Porous Silicon.
Influence of Surface Chemistry on the Release of an Antibacterial Drug from Nanostructured Porous Silicon.
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DOI：
10.1021/acs.langmuir.5b01372
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发表时间：
2015-05
期刊：
影响因子：
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通讯作者：
Mengjia Wang;P. Hartman;A. Loni;L. Canham;Nelli K. Bodiford;J. Coffer
中科院分区：
文献类型：
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作者：
Mengjia Wang;P. Hartman;A. Loni;L. Canham;Nelli K. Bodiford;J. Coffer
纳米结构介孔硅具有有利于药物装载和递送的重要特性。为了控制抗菌药物三氯生的释放及其对金黄色葡萄球菌的相关活性，之前的研究调查了硅基质孔隙率的影响。在这项工作中，我们重点关注表面化学对这些性质的影响的补充问题，特别是可以通过表面修饰进行理想调整的药物装载和释放动力学。由于前者的快速生物再吸收，阳极氧化的、氢化物封端的疏水性多孔硅和氧化的亲水性对应物的药物释放比较复杂。因此，需要具有长期生物稳定性的疏水界面，例如可以由相对长链的辛基部分提供。为了最大限度地减少装载熔融药物物质期间表面可能的热降解或药物活性，已经研究了溶液装载方法。这些研究表明，多孔硅作为持续递送抗菌剂的有效载体的能力可以通过表面功能化敏感地改变。
Nanostructured mesoporous silicon possesses important properties advantageous to drug loading and delivery. For controlled release of the antibacterial drug triclosan, and its associated activity versus Staphylococcus aureus, previous studies investigated the influence of porosity of the silicon matrix. In this work, we focus on the complementary issue of the influence of surface chemistry on such properties, with particular regard to drug loading and release kinetics that can be ideally adjusted by surface modification. Comparison between drug release from as-anodized, hydride-terminated hydrophobic porous silicon and the oxidized hydrophilic counterpart is complicated due to the rapid bioresorption of the former; hence, a hydrophobic interface with long-term biostability is desired, such as can be provided by a relatively long chain octyl moiety. To minimize possible thermal degradation of the surfaces or drug activity during loading of molten drug species, a solution loading method has been investigated. Such studies demonstrate that the ability of porous silicon to act as an effective carrier for sustained delivery of antibacterial agents can be sensitively altered by surface functionalization.