Diminished ouabain-sensitive, sodium-potassium ATPase activity in sciatic nerves of rats with streptozotocin-induced diabetes
Diminished ouabain-sensitive, sodium-potassium ATPase activity in sciatic nerves of rats with streptozotocin-induced diabetes
复制标题
链脲佐菌素诱导的糖尿病大鼠坐骨神经哇巴因敏感性钠钾 ATP 酶活性降低
DOI：
10.1016/0014-4886(76)90299-5
复制
发表时间：
1976
影响因子：
5.3
通讯作者：
M. Rasminsky
中科院分区：
文献类型：
--
作者：
P. Das;G. Bray;A. Aguayo;M. Rasminsky
糖尿病可以通过给予四氧嘧啶或链脲佐菌素在实验动物中产生。与糖尿病患者一样（9），药物诱导的糖尿病动物的外周神经传导速度较慢（3）。糖尿病患者的慢传导速度的形态学相关性被认为是大纤维的损失，髓鞘变薄和节段性脱髓鞘（17）。在患有链脲佐菌素诱导的糖尿病的动物中，周围神经结构是正常的，即使传导速度仍然很慢（13）。因此，必须假定这些动物的神经功能变化是导致冲动传导改变的原因。在实验性糖尿病动物的外周神经中发现了几种生化异常。这些神经含有增加量的山梨醇（6，16）和减少量的肌醇（7）。脂质组成（4，12）和脂质和蛋白质前体掺入外周髓鞘也是异常的糖尿病动物，虽然蛋白质及其多肽成分的量是正常的（15）。尽管髓磷脂组成的异常可以解释在四氧嘧啶糖尿病大鼠中观察到的结间阻力降低（5）），但基于计算机模拟（8，14），结间阻力的变化本身不太可能是对这种降低的充分解释
Diabetes mellitus can be produced in experimental animals by administration of alloxan or streptozotocin. As in diabetic patients (9), peripheral nerve conduction velocities are slow in animals with drug-induced diabetes (3). The morphologic correlates of slow conduction velocities in patients with diabetes are considered to be loss of large fibers, thinning of myelin, and segmental demyelination(17). In animals with streptozotocin-induced diabetes, peripheral nerve structure is normal even though conduction velocities remain slow (13). Thus, it must be assumed that functional changes in the nerves of these animals are responsible for the alteration of impulse conduction.Several biochemical abnormalities have been found in peripheral nerves from animals with experimental diabetes. These nerves contain increased amounts of sorbitol (6, 16) and decreased amounts of myoinositol(7). Lipid composition(4, 12) and the incorporation of lipid and protein precursors into peripheral myelin are also abnormal in diabetic animals although the amount of protein and its polypeptide constituents is normal (15). Although abnormalities of myelin composition might explain the decreased internodal resistance observed in alloxan-diabetic rats (5)) on the basis of computer simulations(8, 14) it is unlikely that the change in internodal resistance is, by itself, a sufficient explanation for the reduction