The Role of Inflammation in Pancreatic Cancer
The Role of Inflammation in Pancreatic Cancer
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DOI：
10.1007/978-3-0348-0837-8_6
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发表时间：
2014-01-01
期刊：
影响因子：
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通讯作者：
Friess, Helmut
中科院分区：
文献类型：
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作者：
Hausmann, Simone;Kong, Bo;Friess, Helmut
胰腺导管腺癌(PDAC)是一种恶性疾病，预后极差。炎症过程已成为胰腺癌发生和发展的关键介质。在基因工程小鼠模型中，胰腺炎的诱导加速了PDAC的发展，众所周知，慢性胰腺炎患者患胰腺癌的风险更高。近年来，人们在确定炎症诱导肿瘤发生的潜在机制方面做了大量工作。已经确定了许多炎症途径，并开发了抑制药物，以防止癌症的发生和发展。在这一章中，我们将讨论炎症通路在胰腺癌发生和发展中的作用，以及抑制物在胰腺癌治疗和预防中的作用。
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with an extremely poor prognosis. Inflammatory processes have emerged as key mediators of pancreatic cancer development and progression. In genetically engineered mouse models, induction of pancreatitis accelerates PDAC development, and patients with chronic pancreatitis are known to have a higher risk of developing pancreatic cancer. In recent years, much effort has been given to identify the underlying mechanisms that contribute to inflammation-induced tumorigenesis. Many inflammatory pathways have been identified and inhibitors have been developed in order to prevent cancer development and progression. In this chapter, we discuss the role of inflammatory pathways in the initiation and progression of pancreatic cancer as well as the role of inhibitors used in treatment and prevention of pancreatic cancer.