Francisella tularensis regulates autophagy-related host cell signaling pathways.

Francisella tularensis regulates autophagy-related host cell signaling pathways.
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DOI:
10.4161/auto.5.1.7305
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发表时间:
2009-01
期刊:
影响因子:
13.3
通讯作者:
Butchar JP
Butchar JP
中科院分区:
生物学1区
文献类型:
--
作者:
Cremer TJ;Amer A;Tridandapani S;Butchar JP

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革兰氏阴性细胞内病原体土拉弗朗西斯菌以其抑制宿主免疫反应的能力而闻名。我们最近进行了一项微阵列分析,比较人类单核细胞对高毒力F。土拉菌S4菌株(F.t.)与毒性较小的F. tularensis novicida(F.n.).许多基因组受到影响,包括那些与自噬和自噬调控有关的基因。在这里,我们讨论的背景下,弗朗西斯菌的毒力和宿主细胞反应的影响,然后得出结论,未来可能的实验。
The Gram-negative intracellular pathogen Francisella tularensis is known for its ability to dampen host immune responses. We recently performed a microarray analsyis comparing human monocyte responses to the highly-virulent F. tularensis tularensis Schu S4 strain (F.t.) versus the less virulent F. tularensis novicida (F.n.). Many groups of genes were affected, including those involved with autophagy and with the regulation of autophagy. Here, we discuss the implications in the context of Francisella virulence and host cell response, then conclude with potential future experiments.
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