EXPERIMENTAL DOUBLE-PERFORATING INJURY OF THE POSTERIOR SEGMENT IN RABBIT EYES - NATURAL-HISTORY OF INTRA-OCULAR PROLIFERATION
EXPERIMENTAL DOUBLE-PERFORATING INJURY OF THE POSTERIOR SEGMENT IN RABBIT EYES - NATURAL-HISTORY OF INTRA-OCULAR PROLIFERATION
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DOI：
10.1001/archopht.1979.01020010387024
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发表时间：
1979-01-01
影响因子：
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通讯作者：
MACHEMER, R
中科院分区：
文献类型：
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作者：
TOPPING, TM;ABRAMS, GW;MACHEMER, R
建立了一种可重复的兔眼后段双穿通伤模型。受伤后，立即在伤口之间可见玻璃状凝结物。巩膜出口伤口在第4天被可能起源于巩膜外层的成纤维细胞增殖封闭，入口伤口在第7天被类似地封闭。起源于伤口的细胞增殖穿过玻璃体损伤道后的玻璃体腔或凝聚的玻璃体到达椎间盘或玻璃体基底。最早的眼内增生，组成的梭形，成纤维细胞样细胞，在第4天。偶尔色素上皮细胞存在于这些增生。其他增生直接发生在邻近伤口的视网膜表面。经玻璃体增殖采用玻璃体作为支架，而表面增殖使用视网膜表面进行接触引导。
A reproducible model of double perforating injury of the posterior segment of the rabbit eye was developed. Immediately after injury, a vitreous condensation was visible between wounds. The scleral exit wound was sealed by fibroblastic proliferation of probable episcleral origin by the 4th day and the entrance similarly by the 7th day. Cellular proliferations originating in the wounds crossed the vitreous cavity following the vitreous injury tract or condensed vitreous to the disc or to the vitreous base. The earliest intraocular proliferations, composed of spindle-shaped, fibroblast-like cells, were seen at day 4. Occasional pigment epithelia were present in and on these proliferations. Other proliferations occurred directly on the retinal surface adjacent to the wounds. The transvitreous proliferations employed the vitreous as a scaffold, while the surface proliferations used the retinal surface for contact guidance.