Layer-Specific BOLD Activation in Human VI
Layer-Specific BOLD Activation in Human VI
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DOI：
10.1002/hbm.20936
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发表时间：
2010-09-01
影响因子：
4.8
通讯作者：
Norris, David G.
中科院分区：
文献类型：
--
作者：
Koopmans, Peter J.;Barth, Markus;Norris, David G.
众所周知，新皮层具有独特的层流结构，这一结构此前已在动物身上使用高分辨率功能磁共振成像（fMRI）进行了探测。然而，迄今为止，在人类中检测层特异性激活被证明是难以捉摸的。在这项研究中，我们首次展示了这种层特异性激活，特别是在与人类初级视觉皮层（V1）的第四层相对应的深度。我们使用了梯度回波（GE）序列，在3T的各向同性分辨率为0.75 mm，其中第四层深度的条纹在平均时间序列中可见。在视觉刺激（7.5 Hz闪烁棋盘）下，第四层的信号增加3%，明显高于邻近的椎板。基于这一结果和已知的皮层内脉管层流组织，我们得出结论，在垂直于皮层表面的方向上，GE-BOLD功能磁共振成像信号的固有空间分辨率在亚毫米范围内，人类层流功能磁共振成像是一项重要的发展，它可以提高我们对皮层内激活模式和不同皮层区域相互作用方式的理解。中国生物医学工程学报，2010(3):559 - 563。公司
The neocortex is known to have a distinct laminar structure which has previously been probed in animals using high-resolution fMRI. Detection of layer-specific activation in humans has however to date proven elusive. In this study we demonstrate for the first time such layer-specific activation, specifically at a depth corresponding to layer IV of human primary visual cortex (V1) We used a gradient-echo (GE) sequence at 3T with an isotropic resolution of 0 75 mm, in which a stria at the depth of layer IV was visible in the averaged time series, and could be used as an anatomical landmark Upon visual stimulation (7.5 Hz flickering checkerboard) the signal increase of 3% in layer IV was significantly higher than in the neighboring laminae. The width of this activation peak was 0 8-1 min Based on this result and known laminar organization of the intracortical vasculature we conclude that in the direction perpendicular to the cortical surface the intrinsic spatial resolution of the GE-BOLD fMRI signal is in the submillimetre range Human laminar fMRI is a significant development which may improve our understanding of intracortical activation patterns and of the way in which different cortical regions interact. Hum Brain Mapp 31 1297-1304, 2010 (C) 2010 Wiley-Liss. Inc