Three forebrain structures directly inform the auditory midbrain of echolocating bats
Three forebrain structures directly inform the auditory midbrain of echolocating bats
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DOI：
10.1016/j.neulet.2019.134481
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发表时间：
2019-11-01
影响因子：
2.5
通讯作者：
Honma, Satoru
中科院分区：
文献类型：
--
作者：
Ito, Tetsufumi;Yamamoto, Ryo;Honma, Satoru
回声定位蝙蝠会发出各种类型的声音用于导航和交流，需要注意声音。从前脑中心到听觉中心的投射涉及对发声的关注，其中下丘（IC）是投射的主要目标。在这里，使用逆行示踪剂，我们证明了三个前脑结构，即内侧前额叶皮层（mPFC）、杏仁核和听觉皮层（AC），将直接下降的投射发送到 IC 的中央核。我们发现所有三个结构都投射到双边 IC。动物间逆行标记细胞模式的比较表明，同侧 AC-IC 投影是按地形组织的，而 mPFC-IC 或杏仁核-IC 投影没有显示出清晰的地形组织。结合之前研究的证据，这些结果表明，大脑皮质的三个下降投射在前脑和大脑皮质之间形成循环，以引起对各种声音的注意。
Echolocating bats emit various types of vocalizations for navigation and communication, and need to pay attention to vocal sounds. Projections from forebrain centers to auditory centers are involved in the attention to vocalizations, with the inferior colliculus (IC) being the main target of the projections. Here, using a retrograde tracer, we demonstrate that three forebrain structures, namely, the medial prefrontal cortex (mPFC), amygdala, and auditory cortex (AC), send direct descending projections to the central nucleus of IC. We found that all three structures projected to the bilateral IC. A comparison of the patterns of retrogradely labeled cells across animals suggests that the ipsilateral AC-IC projection is topographically organized, whereas mPFC-IC or amygdala-IC projections did not show clear topographic organization. Together with evidence from previous studies, these results suggest that three descending projections to the IC form loops between the forebrain and IC to make attention to various vocal sounds.