Effect of farnesol on Candida dubliniensis biofilm formation and fluconazole resistance
Effect of farnesol on Candida dubliniensis biofilm formation and fluconazole resistance
复制标题
DOI：
10.1111/j.1567-1364.2006.00121.x
复制
发表时间：
2006-11-01
影响因子：
3.2
通讯作者：
Meiller, Timothy
中科院分区：
文献类型：
--
作者：
Jabra-Rizk, Mary Ann;Shirtliff, Mark;Meiller, Timothy
都柏林念珠菌和白色念珠菌是具有多种致病能力的二型真菌，包括生物膜形成、全身感染和氟康唑耐药性的发展。在这项研究中，法尼醇破坏这些毒力的能力进行了调查。生物膜评估和敏感性研究表明，法尼醇对两个物种的抗真菌和抗真菌膜的特性，对细胞膜的破坏性影响。法尼醇和氟康唑在耐药菌株中的协同试验导致氟康唑耐药性的逆转，表明法尼醇作为辅助治疗剂的潜在应用。
Candida dubliniensis and Candida albicans are dimorphic fungal species with a number of pathogenic capabilities, including biofilm formation, systemic infection and development of fluconazole resistance. In this study, the ability of farnesol to disrupt these virulence capabilities was investigated. Biofilm assessment and susceptibility studies indicated antifungal and antibiofilm properties for farnesol on both species with a disruptive effect on the cell membrane. Synergy testing of farnesol and fluconazole in resistant strains resulted in reversal of fluconazole resistance, indicating a potential application for farnesol as an adjuvant therapeutic agent.