Short term resistance training enhanced plasma apoA-I and FABP4 levels in Streptozotocin-induced diabetic rats.
Short term resistance training enhanced plasma apoA-I and FABP4 levels in Streptozotocin-induced diabetic rats.
复制标题
短期耐药性训练增强了链蛋白酶诱导的糖尿病大鼠的血浆APOA-I和FABP4水平。
DOI：
10.1186/2251-6581-13-41
复制
发表时间：
2014-03-04
影响因子：
2.8
通讯作者：
Talebi-Garakani E
中科院分区：
文献类型：
--
作者：
Safarzade A;Talebi-Garakani E
1型糖尿病与早期动脉粥样硬化并发症的高风险相关。慢性糖尿病患者血脂和脂蛋白代谢改变与动脉粥样硬化等心血管疾病的发病机制有关。观察4周耐力训练对1型糖尿病大鼠血脂、脂肪酸结合蛋白(FABP)4和载脂蛋白(Apo)A-I水平的影响。选用12~14周龄雄性Wistar大鼠32只，随机分为4组：非糖尿病对照组、非糖尿病训练组、糖尿病对照组、糖尿病训练组。训练组的大鼠接受阻力训练计划(3天/周，持续4周)，包括爬梯子携带从尾部悬挂的负荷。糖尿病组血浆载脂蛋白A-I水平较非糖尿病对照组升高(P<0.001)，FABP_4水平较非糖尿病对照组降低(P<0.05，P<0.01)，与非糖尿病对照组比较差异有统计学意义(P<0.05，P<0.01，P<0.05， = <0.05，P<0.05，糖尿病组与非糖尿病对照组比较，血浆载脂蛋白A-I升高(P<0.05，P<0.01)，FABP_4水平降低(P<0.05，P<0.05，P<0.05，抗阻训练4周后，糖尿病训练组大鼠血浆载脂蛋白A-I和载脂蛋白4水平显著高于糖尿病对照组(分别为P = 0.003和P = 0.017)。糖尿病训练组血浆高密度脂蛋白胆固醇水平高于糖尿病对照组(P = 0.048)。两个训练组(非糖尿病组和糖尿病组)的肝脏甘油三酯浓度均显著低于其对照组(分别为P = 0.041和P = 0.002)。这些数据表明，阻力训练可能是一种有效的干预策略，可以提高链脲佐菌素诱导的糖尿病大鼠血浆载脂蛋白A-I、高密度脂蛋白-C和FABP4的浓度，降低肝脏甘油三酯的水平。需要进一步的研究来阐明循环FABP4水平的生理意义。
Type 1 diabetes mellitus is associated with a high risk for early atherosclerotic complications. Altered lipids and lipoprotein metabolism in chronic diabetes mellitus is associated with pathogenesis of atherosclerosis and other cardiovascular diseases. The aim of this study was to investigate the effects of 4 weeks resistance training on plasma lipid profile, fatty acid binding protein (FABP) 4 and apolipoprotein (apo) A-I levels in type 1 diabetic rats. Thirty two male Wister rats (12–14 weeks old) were randomly divided into four groups: non-diabetic control; non-diabetic trained; diabetic control; diabetic trained. The rats in training groups were subjected to a resistance training program (3 days/wk, for 4 wk) consisted of climbing a ladder carrying a load suspended from the tail. Diabetic inducing increased plasma apoA-I and decreased FABP4 levels compared with non-diabetic control group (respectively, P = 0.001 & P = 0.041). After 4 weeks’ resistance training, plasma levels of apoA-I and FABP4 in the diabetic trained rats were significantly higher compared with the diabetic control group (respectively, P = 0.003 & P = 0.017). Plasma HDL-C level in diabetic trained group was higher than diabetic control group (P = 0.048). Liver triglycerides concentrations were significantly lower in both trained (non-diabetic and diabetic) groups compared with their control groups (respectively, P = 0.041 and P = 0.002). These data indicated that resistance training may be an efficient intervention strategy to increase plasma apoA-I, HDL-C and FABP4 concentrations, along with decreases liver triglycerides in streptozotocin induced diabetic rats. Further research is needed to elucidate physiological significance of circulating FABP4 levels.