Moderate intensity treadmill exercise alters food preference via dopaminergic plasticity of ventral tegmental area-nucleus accumbens in obese mice
Moderate intensity treadmill exercise alters food preference via dopaminergic plasticity of ventral tegmental area-nucleus accumbens in obese mice
复制标题
中等强度的跑步机运动通过肥胖小鼠腹侧被盖区伏核的多巴胺能可塑性改变食物偏好
DOI：
10.1016/j.neulet.2017.01.055
复制
发表时间：
2017-02-22
影响因子：
2.5
通讯作者：
Li, Qiong
中科院分区：
文献类型：
--
作者：
Chen, Wei;Wang, Hai Jun;Li, Qiong
肥胖与过量摄入美味食物和缺乏运动有关。为了探讨运动诱导的肥胖预防和治疗的神经生物学机制，本研究考察了跑步机运动对小鼠对美味食物偏好的影响。还分析了腹侧被盖区-伏隔核系统中酪氨酸羟化酶（TH）的水平，以及伏隔核中多巴胺、多巴胺转运体和D2受体的水平。将40只C57BL/6J小鼠随机分为对照组（CG, n = 10）和高脂饮食组（HG, n = 30）。HG组小鼠连续12周饲喂高脂饲料，建立肥胖模型，然后将肥胖小鼠随机分为肥胖对照组（OG, n =11）和肥胖+运动组（OEG, n = 12）。OEG小鼠接受8周的跑步机运动干预。我们的研究结果表明，相对于OG组的动物，OEG小鼠对高脂肪饮食的偏好和胰岛素抵抗显著降低，同时对蔗糖和牛奶的偏好、TH和D2受体的表达以及腹侧被盖区-伏隔核系统的多巴胺水平增加。这些结果表明，中等强度的跑步机运动可以改变肥胖小鼠的食物偏好，这可能是通过腹侧被盖区-伏隔核的多巴胺能可塑性和胰岛素敏感性增强介导的。(C) 2017 Elsevier B.V.版权所有
Obesity has been associated with the excessive intake of palatable food as well as physical inactivity. To investigate the neurobiological mechanism underlying the exercised-induced prevention and treatment of obesity, the present study examined the effect of treadmill exercise on the preference for palatable food in mice. Levels of tyrosine hydroxylase (TH) in the ventral tegmental area-nucleus accumbens system were also analysed, as well as levels of dopamine, dopamine transporter, and D2 receptors in the nucleus accumbens. Forty C57BL/6J mice were randomly divided into a control group (CG, n = 10) and a high-fat diet group (HG, N = 30). Mice of the HG group were fed a high-fat diet for 12 weeks in order to induce a model of obesity, following which the obese mice were randomly divided into an obese control group (OG, n =11) and an obese+ exercise group (OEG, n = 12). OEG mice received 8 weeks of treadmill exercise intervention. Our results indicate that, relative to animals in the OG group, OEG mice exhibited significant decreases in the preference for high-fat diets and insulin resistance, along with increases in the preference for sucrose and milk, TH and D2 receptor expression, and levels of dopamine in the ventral tegmental area-nucleus accumbens system. These results suggest that moderate-intensity treadmill exercise can alter food preference in obese mice, which may be mediated by dopaminergic plasticity of the ventral tegmental area-nucleus accumbens and enhanced insulin sensitivity. (C) 2017 Elsevier B.V. All rights reserved.