The eye-specification proteins so and eya form a complex and regulate multiple steps in Drosophila eye development
The eye-specification proteins so and eya form a complex and regulate multiple steps in Drosophila eye development
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DOI：
10.1016/s0092-8674(00)80480-8
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发表时间：
1997-12-26
期刊：
影响因子：
64.5
通讯作者：
Zipursky, SL
中科院分区：
文献类型：
--
作者：
Pignoni, F;Hu, BR;Zipursky, SL
sine oculis（so）和eyes absent（eya）是果蝇眼睛发育所必需的，并且是哺乳动物Six和Eya基因家族的创始成员。这些基因已经被提出与无眼（Pax 6）一起作用，以调节脊椎动物和无脊椎动物的眼睛发育。S 0编码高度分化的同源异型盒转录因子，Eya编码新的核蛋白。我们证明了So和Eya（1）调节眼睛发育中的常见步骤，包括细胞增殖，图案化和神经元发育;（2）在诱导异位眼中协同作用;（3）通过进化保守的结构域在酵母和体外相互作用。我们提出，一个So/Eya复杂的调节多个步骤在眼睛的发展和功能的背景下，一个网络的基因，以指定眼睛组织的身份。
sine oculis (so) and eyes absent (eya) are required for Drosophila eye development and are founding members of the mammalian Six and Eya gene families. These genes have been proposed to act with eyeless (Pax6) to regulate eye development in vertebrates and invertebrates. so encodes a highly diverged homeobox transcription factor and eya encodes a novel nuclear protein. We demonstrate that So and Eya (1) regulate common steps in eye development including cell proliferation, patterning, and neuronal development; (2) synergize in inducing ectopic eyes; and (3) interact in yeast and in vitro through evolutionarily conserved domains. We propose that an So/Eya complex regulates multiple steps in eye development and functions within the context of a network of genes to specify eye tissue identity.