Sham TMS: Intracerebral measurement of the induced electrical field and the induction of motor-evoked potentials
Sham TMS: Intracerebral measurement of the induced electrical field and the induction of motor-evoked potentials
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DOI：
10.1016/s0006-3223(00)01110-0
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发表时间：
2001-03-01
影响因子：
10.6
通讯作者：
Sackeim, HA
中科院分区：
文献类型：
--
作者：
Lisanby, SH;Gutman, D;Sackeim, HA
在对照试验中测试经颅磁刺激（TMS）的治疗潜力需要有效的假手术条件。假经颅磁刺激通常是通过将线圈倾斜45-90度离开头皮，使线圈的一个或两个翼接触头皮来施用的。缺乏皮层效应尚未得到证实。我们比较了人类志愿者的运动诱发电位（MEP）阈值和恒河猴前额叶皮层诱导电压的脑内测量。三种类型的假操作（单翼45度和90度以及两翼90度倾斜）在大脑中诱导的电压比主动TMS低得多然而，两翼45度假手术诱导的值仅比活动TMS低24%，这种假手术诱导运动皮层MEP的效力约为活动TMS的一半。生物精神病学2001;49：460-463（C）2001生物精神病学学会。
Testing the therapeutic potential of transcranial magnetic stimulation (TMS) in controlled trials requires a valid sham condition. Sham TMS is typically administered by tilting the coil 45-90 degrees off the scalp, with one or two wings of the coil touching the scalp. Lack of cortical effects has not been verified.We compared sham manipulations in their thresholds for eliciting motor-evoked potentials (MEPs) in human volunteers and in intracerebral measurements of voltage induced in the prefrontal cortex of a rhesus monkey.Three types of sham (one-wing 45 degrees and 90 degrees and two-wing 90 degrees tilt) induced much lower voltage in the brain than active TMS (67-73% reductions), However, the two-wing 45 degrees sham induced values just 24% below active TMS, This sham was about half as potent in inducing MEPs over the motor cortex as active TMS.Some sham TMS conditions produce substantial cortical stimulation, making it critical to carefully select the sham manipulation for clinical trials. Biol Psychiatry 2001;49: 460-463 (C) 2001 Society of Biological Psychiatry.