High-Intensity Aerobic Exercise Improves Both Hepatic Fat Content and Stiffness in Sedentary Obese Men with Nonalcoholic Fatty Liver Disease.
High-Intensity Aerobic Exercise Improves Both Hepatic Fat Content and Stiffness in Sedentary Obese Men with Nonalcoholic Fatty Liver Disease.
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DOI：
10.1038/srep43029
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发表时间：
2017-02-22
影响因子：
4.6
通讯作者：
Shoda J
中科院分区：
文献类型：
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作者：
Oh S;So R;Shida T;Matsuo T;Kim B;Akiyama K;Isobe T;Okamoto Y;Tanaka K;Shoda J
我们比较了为期12周的阻力训练(RT)、高强度间歇有氧训练(HIAT)和中等强度连续有氧训练(MICT)的效果。主要目标是评估运动方式对非酒精性脂肪性肝病(NAFLD)的治疗效果。共有61名患有NAFLD的久坐肥胖男性被随机分成以下运动方案之一(RT、HIAT或MICT)。RT、HIAT和MICT组的肝脏脂肪含量降低程度相似(−为14.3%，−为13.7%，−为14.3%)，而体重和内脏脂肪没有明显变化。受试者单核细胞中脂肪酸合成的基因表达水平显著降低。仅HIAT组肝脏硬度降低(−为16.8%)。僵硬改变与库普弗细胞吞噬功能恢复(+17.8%)和炎症水平降低有关，如瘦素(−13.2%)和铁蛋白(−14.1%)。RT、HIAT和MICT在降低肝脏脂肪含量方面同样有效，但只有HIAT在改善肝脏僵硬和恢复Kupffer细胞功能方面有效。这些好处似乎独立于可检测到的体重和内脏脂肪减少；这些好处是通过调节体内脂肪酸代谢和肥胖相关的炎症条件而获得的。
We compared the effects of 12-week programs of resistance training (RT), high-intensity interval aerobic training (HIAT), and moderate-intensity continuous aerobic training (MICT). The primary goal was to evaluate the therapeutic effects of the exercise modalities for the management of nonalcoholic fatty liver disease (NAFLD). A total of 61 sedentary obese men with NAFLD were randomized into one of the following exercise regimens (RT, HIAT, or MICT). Hepatic fat content was decreased to a similar extent in the RT, HIAT, and MICT groups (−14.3% vs. −13.7% vs. −14.3%) without significant changes in weight and visceral fat. The gene expression levels of fatty acid synthesis were significantly decreased in the subjects’ monocytes. Hepatic stiffness was decreased only in the HIAT group (−16.8%). The stiffness change was associated with restored Kupffer cell phagocytic function (+17.8%) and decreased levels of inflammation such as leptin (−13.2%) and ferritin (−14.1%). RT, HIAT, and MICT were equally effective in reducing hepatic fat content, but only HIAT was effective in improving hepatic stiffness and restoring Kupffer cell function. These benefits appeared to be independent of detectable weight and visceral fat reductions; the benefits were acquired through the modulation of in vivo fatty acid metabolism and obesity-related inflammatory conditions.