HLA-B*51 and B*15 alleles confer predisposition to Behcet's disease in Moroccan patients
HLA-B*51 and B*15 alleles confer predisposition to Behcet's disease in Moroccan patients
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DOI：
10.1016/s0198-8859(00)00249-4
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发表时间：
2001-02-01
期刊：
影响因子：
2.7
通讯作者：
Caillat-Zucman, S
中科院分区：
文献类型：
--
作者：
Choukri, F;Chakib, A;Caillat-Zucman, S
到目前为止，摩洛哥白塞病患者的人类白细胞抗原I类基因多态性尚未得到研究。在这项研究中，分析了86例无血缘关系的摩洛哥患者(男性45例，女性41例)和111名种族匹配的健康对照组的HLA-B*表型频率。B*51基因的易感效应在患者组和对照组分别为30.2%和15.3%，OR=2.39，95%CI[1.2~4.8]，P=0.015。多见于发病年龄较小的男性(与对照组相比，OR=5.5[1.9~15.9]，P=0.002)。摩洛哥ED组也表现出以前未知的与人类白细胞抗原B*15的关联(25.6%的患者和11.7%的对照组，OR=2.59[1.1-5.5]，P=0.014)，无论是在女性还是在男性发病较晚的患者中。总体而言，B*15和/或B*51等位基因在55.8%的患者中表达，而在对照组中的表达比例为27%(OR=3.41.9-6.2p<；10-4，Pc=0.003)。提示人类白细胞抗原-B在勃起功能障碍发病机制中的作用应男女分开考虑。(C)美国组织相容性和免疫遗传学会，2001年。爱思唯尔科学公司出版。
HLA class I polymorphism in Moroccan patients with Behcet's disease has not been investigated so far. In this study, HLA-B* phenotype frequencies were analyzed in 86 unrelated Moroccan patients (45 males, 41 females) and 111 ethnically matched healthy controls. The predisposing effect of the B*51 was confirmed (30.2% in patients and 15.3% in controls, OR = 2.39, 95% CI [1.2-4.8], P = 0.015). It was mostly observed in males with young age at disease onset (OR = 5.5 [1.9-15.9], P = 0.002 compared to controls). The Moroccan ED group also presented a previously unknown association with HLA-B*15 (25.6% of patients versus 11.7% of controls, OR = 2.59 [1.1-5.5], P = 0.014), both in females and in males with late-onset of the disease. Altogether, the B*15 and/or B*51 alleles were expressed in 55.8% of patients compared to 27% of controls (OR = 3.4 [1.9-6.2], p < 10-4, Pc = 0.003). Our data indicate HLA-B effects on ED pathogenesis should be considered separately fur men and women. (C) American Society for Histocompatibility and Immunogenetics, 2001. Published by Elsevier Science Inc.