Nanotechnology enabled regenerative medicine for neurological disorders.
Nanotechnology enabled regenerative medicine for neurological disorders.
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纳米技术使神经系统疾病的再生医学成为可能。
DOI：
10.1016/j.addr.2019.11.006
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发表时间：
2019
影响因子：
16.1
通讯作者：
Kannan,Sujatha
中科院分区：
文献类型：
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作者：
Lowe,TaoL;Agrahari,Vivek;Kannan,RangaramanujamM;Kannan,Sujatha
近年来，再生疗法取得了显着的发展，有前景的方法可以恢复患病、受损和老化的组织和器官的功能。这是一个高度跨学科的领域，通过生物工程、干细胞生物学和纳米技术的最新进展的交叉而成为可能。与传统技术相比，纳米技术的结合可以更好地控制生物材料的物理化学和生物特性。纳米技术在再生治疗中的应用具有彻底改变组织再生和修复以及最终个性化医疗的潜力。本期《Advanced Drug Delivery Review》主题对利用纳米技术治疗神经系统疾病的再生疗法的最新进展、未来方向以及可能面临的挑战进行了全面而批判性的评论。本期涵盖了基于纳米技术的系统在中枢神经系统（CNS）（包括大脑和脊髓、眼睛和周围神经再生）中的制造、表征、成像和治疗应用。它还详细回顾了纳米技术在加速再生神经医学干细胞研究和开发方面的进展。此外，本主题讨论了纳米神经毒性和纳米医学临床转化的障碍以及神经系统再生和修复纳米载体的临床前评估策略。纳米材料作为理解中枢神经系统疾病病理学的工具，神经可塑性作为基于生物材料的中风疗法的目标，纳米治疗学作为神经系统疾病个性化医疗的组合诊断和治疗实体，纳米材料作为基因传递装置来重新编程细胞以实现眼再生，纳米材料作为免疫调节剂来恢复神经元再生的健康免疫系统，以及使用斑马鱼作为评估神经再生疗法的模型，这些都是本期主题中的一些独特且有前途的主题。
Regenerative therapy has evolved significantly in recent years with promising approaches to restore function of diseased, damaged and aged tissues and organs. It is a highly interdisciplinary field that has been made possible by the intersection of recent advances in bioengineering, stem cell biology and nanotechnology. Incorporation of nanotechnology may allow better control over physicochemical and biological properties of a biomaterial compared to conventional technologies. Nanotechnology applications to regenerative therapy have all the potential to revolutionize tissue regeneration and repair, and ultimately personalized medicine. This theme issue of Advanced Drug Delivery Review provides comprehensive and critical reviews of recent developments, future directions, and possible challenges in advancing regenerative therapy for treating neurological disorders using nanotechnology. This issue has covered the fabrication, characterization, imaging, and theranostic applications of nanotechnology-based systems in central nervous system (CNS) including brain and spinal cord, eye and peripheral nerve regeneration. It also reviews in detail the progress of nanotechnology in speeding up stem cell research and development for regenerative neurological medicine. Furthermore, this theme issue discusses nanoneurotoxicity and hurdles in nanomedicine clinical translation and strategies for preclinical evaluation of nanocarriers for regeneration and repair in the nervous system. Nanomaterials as tools for understanding CNS disease pathology, neuroplasticity as a target for biomaterial-based therapies for stroke, nanotheranostics as a combined diagnostic and therapeutic entity for personalized medicine in neurological disorders, nanomaterials as gene delivery devices to reprogram cells for ocular regeneration, nanomaterials as immunomodulators to restore healthy immune system for neuronal regeneration, and the use of zebrafish as a model for evaluating neuroregenerative therapeutics are some of the unique and promising topics featured in this theme issue.