Artificial trachea and long term follow-up in carinal reconstruction in dogs
Artificial trachea and long term follow-up in carinal reconstruction in dogs
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DOI：
10.1177/039139880002301010
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发表时间：
2000-10-01
影响因子：
1.7
通讯作者：
Shimizu, Y
中科院分区：
文献类型：
--
作者：
Nakamura, T;Teramachi, M;Shimizu, Y
我们已经报道了成功的气管隆突重建，观察期为1 - 2年。在这项研究中，我们在随访5年后评估了重建的长期安全性和有效性。Y形Marlex（R）网状管用聚丙烯螺旋加固，并涂有猪皮制成的去端胶原。假体长60 mm，外径18 mm。通过右胸廓切开术在比格犬中进行气管支气管分叉置换。定期行支气管镜检查和气管上皮取样，检查纤毛功能，植入假体迅速被周围结缔组织浸润，并完全被宿主气管和支气管吸收。支气管镜检查证实从吻合口上部到下部均有充分的上皮形成。5年后，未观察到狭窄或裂开。尽管管腔表面存在补片暴露，但犬在处死进行病理学检查之前没有临床症状。纤毛的弯曲频率维持在正常范围内，表明再生气道的功能恢复。我们的气管假体有望用于气管支气管分叉的临床修复。
We have already reported successful carinal reconstruction of the trachea with an observation period of 1 - 2 years. In this study, we evaluate the long-term safety and efficacy of the reconstruction after 5-years of follow-up.The Y-shaped Marlex(R) mesh tube was reinforced with a polypropylene spiral and coated with atelocollagen made from porcine skin. The prosthesis was 60 mm long with an outer diameter of 18 mm. Replacement of the tracheobronchial bifurcation was preformed through a right thoracotomy in a beagle dog. Bronchoscopical examination and sampling of the tracheal epithelium was performed periodically to check the function of cilia.The implanted prothesis was promptly infiltrated by the surrounding connective tissue and completely incorporated by the host trachea and bronchus. Bronchoscopically, sufficient epithelization was confirmed from the upper to the lower site of anastomosis. After 5 years neither stenosis nor dehiscence was observed. In spite of there being mesh-exposure at the luminal surface, the dog had no clinical symptoms until sacrifice for pathological examination. The bent frequency of the cilia was maintained within the normal range, indicating functional recovery of the regenerating airwayOur tracheal prosthesis is promising for clinical repair of the tracheobronchial bifurcation.