Sedative use and misuse in the United States
Sedative use and misuse in the United States
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DOI：
10.1046/j.1360-0443.2002.00098.x
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发表时间：
2002-05-01
期刊：
影响因子：
6
通讯作者：
Hasin, DS
中科院分区：
文献类型：
--
作者：
Goodwin, RD;Hasin, DS
目的了解普通人群中镇静剂使用和滥用的流行情况及相关因素。方法采用全国共病调查（National Comobidity Survey，n = 8098）的数据，对社区中具有代表性的成年人进行抽样调查。结果自我感觉的镇静剂依赖的终生患病率为0.5%，非处方镇静剂使用率为7.1%，处方镇静剂使用率为17.0%。没有处方而使用镇静剂的人更有可能成为伴侣。（OR = 0.61（0.44，0.86）），收入较低（OR = 0.71（0.54，0.94）），文化程度高（OR = 1.51，（1.17，1.96）），重性抑郁（OR = 1.47（1.04，2.08））、广场恐怖（OR 1.59 ± 2.32））、反社会人格障碍（OR = 5.29（3.42，8.20））和自杀意念（OR 1.91（1.23，2.94））。自我感觉依赖镇静剂的个体年龄较大，（OR = 1.05（1.02，1.08）），文化程度低（OR = 0.2（0.1，0.7）），并且更有可能有滥用处方药的父母（OR = 4.3（1.03，18.03））。结论近1/10的成年人在其一生中报告滥用镇静剂。镇静剂的使用和滥用与高水平的精神病理学和自杀风险相关，并显示出与一般人群中父母滥用处方药的特定相关性。未来的工作，更有效地了解这些协会的性质可能最终导致预防干预措施的有效性提高。
Objective To determine the prevalence and correlates associated with sedative use and misuse in the general population.Method Data were drawn front the National Comobidity Survey (n = 8098), a representative sample of adults in the community. Multivariate logistic regression analyses were used to identify correlates of sedative use, non-prescription use and self-perceived dependence.Results The life-time prevalence of self-perceived sedative dependence was 0.5%, 7.1'% reported non-prescribed sedative use and 17.0% had been prescribed sedatives and denied misuse. Individuals who used sedatives without a prescription were more likely to be mate (OR = 0.61 (0.44, 0.86)), have lower income (OR = 0.71 (0.54, 0.94)), more education (OR = 1.51, (1.17, 1.96)), major depression (OR = 1.47 (1.04, 2.08)), agoraphobia (OR 1.59 l 2.32)), ASPD (OR = 5.29 (3.42, 8.20)) and suicide ideation (OR 1.91 (1.23, 2.94)), compared with those who did not use sedatives. Individuals with self-perceived dependence on sedatives were older (OR = 1.05 (1.02, 1.08)), had less education (OR = 0.2 (0.1, 0.7)) and were more likely to have a parent who abused prescription medications (OR = 4.3 (1.03, 18.03)), compared with those without sedative dependence.Conclusions Almost one in 10 Adults report misuse of sedatives in their lifetime. Sedative use and misuse arc associated with high levels of psychopathology and suicide risk, and show a specific association with parental abuse of prescription medications in the general population. Future work to understand more effectively the nature of these associations may ultimately lead to improved effectiveness of preventive interventions.