Catalytic enantioselective electrophilic α-hydrazination of β-ketoesters using bifunctional organocatalysts
Catalytic enantioselective electrophilic α-hydrazination of β-ketoesters using bifunctional organocatalysts
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DOI：
10.1016/j.tetlet.2008.07.041
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发表时间：
2008-09-15
影响因子：
1.8
通讯作者：
Kim, Dae Young
中科院分区：
文献类型：
--
作者：
Jung, Sun Hee;Kim, Dae Young
报道了手性双功能有机催化剂促进的对映选择性亲电α-肼化反应。在温和的反应条件下，用偶氮二羧酸酯作为亲电胺化试剂处理β-酮酯，得到具有优异对映体过量（93- 99%ee）的相应α-氨基β-酮酯。(C)2008爱思唯尔有限公司保留所有权利。
The catalytic enantioselective electrophilic alpha-hydrazination promoted by chiral bifunctional organocatalysts is described. Treatment of beta-ketoesters with azodicarboxylates as electrophilic amination reagents under mild reaction conditions afforded the corresponding alpha-amino beta-ketoesters with excellent enantiomeric excesses (93-99% ee). (C) 2008 Elsevier Ltd. All rights reserved.