AMPHETAMINE, APOMORPHINE AND INVESTIGATORY BEHAVIOR IN THE RAT - ANALYSIS OF THE STRUCTURE AND PATTERN OF RESPONSES
AMPHETAMINE, APOMORPHINE AND INVESTIGATORY BEHAVIOR IN THE RAT - ANALYSIS OF THE STRUCTURE AND PATTERN OF RESPONSES
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DOI：
10.1007/bf00310515
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发表时间：
1986-01-01
影响因子：
3.4
通讯作者：
STINUS, L
中科院分区：
文献类型：
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作者：
KELLEY, AE;WINNOCK, M;STINUS, L
在本实验中，在自动八孔盒中研究了大剂量的d-苯丙胺和阿扑吗啡对大鼠行为的影响。安非他明（0.125，0.25，0.5，1.0，3.0，5.0毫克/公斤）增加的频率和总的反应持续时间，并以剂量依赖性的方式减少平均持续时间。的战略和组织的反应，作为衡量孔访问和孔开关的顺序，在较低剂量的安非他明不变，但在较高剂量的改变。在最高剂量（5.0）下观察到持续性戳孔，如每次访视戳孔次数增加所示。阿扑吗啡（0.05，0.1，0.2，0.4，0.8，1.6，3.2毫克/公斤）的平均持续时间的反应，但与安非他明显着减少的频率。还在两种药物的所有剂量下测量自发活动。我们的观察结果表明，这两种兴奋剂药物，这两个增加运动活动，有显着不同的影响，对解释性反应。很可能安非他明增加了优势反应倾向（即，钻漏洞），尽管这并不一定反映了勘探的加强。此外，安非他明获得的结果支持由Lyon-Robbins安非他明效应的行为理论所作的预测。
In the present experiments, the effects of a wide range of doses of d-amphetamine and apomorphine were studied on investigatory behavior in an automated eight-hole box. Amphetamine (0.125, 0.25, 0.5, 1.0, 3.0, 5.0 mg/kg) increased frequency and total duration of responses, and decreased mean duration in a dose-dependent manner. The strategy and organization of responses, as measured by the order of hole-visits and hole-switching, were unchanged at lower doses of amphetamine but were altered at higher doses. Perseverative hole-poking was observed at the highest dose (5.0) as indicated by increased number of hole-pokes per hole-visit. Apomorphine (0.05, 0.1, 0.2, 0.4, 0.8, 1.6, 3.2 mg/kg) decreased mean duration of responses, but in contrast to amphetamine markedly diminished frequency. Locomotor activity was also measured at all doses of both drugs. Our observations indicate that these two stimulant drugs both of which increase motor activity, have markedly different effects on investigatory responses. It is likely that amphetamine increases prepotent response tendencies (i.e., hole-poking), although this does not necessarily reflects enhanced exploration. Further, the results obtained with amphetamine support predictions made by the Lyon-Robbins behavioral theory of amphetamine effects.