Hemisynthesis of rhazinilam analogues: Structure-activity relationships on tubulin-microtubule system
Hemisynthesis of rhazinilam analogues: Structure-activity relationships on tubulin-microtubule system
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DOI：
10.1016/s0960-894x(97)00391-0
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发表时间：
1997-09-09
影响因子：
2.7
通讯作者：
Guenard, D
中科院分区：
文献类型：
--
作者：
David, B;Sevenet, T;Guenard, D
抗微管蛋白化合物rhazinilam的衍生物的半合成描绘了生物活性所必需的一些分子特征。在这项研究的过程中，形成的rhazinilam从1，2-二脱氢aspidospermidine重新审查，并提出了一个新的机制。(C)1997 Elsevier Science Ltd.
Semi-synthesis of derivatives of rhazinilam, an antitubulin compound, delineated some molecular features necessary for biological activity. In the course of this study, the formation of rhazinilam from 1,2-didehydroaspidospermidine is reexamined and a new mechanism is proposed. (C) 1997 Elsevier Science Ltd.