Increased Mauthner cell activity and escaping behaviour in seabream fed long-chain PUFA
Increased Mauthner cell activity and escaping behaviour in seabream fed long-chain PUFA
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DOI：
10.1017/s0007114511002807
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发表时间：
2012-01-28
影响因子：
3.6
通讯作者：
Soledad Izquierdo, Maria
中科院分区：
文献类型：
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作者：
Benitez-Santana, Tibiabin;Juarez-Carrillo, Eduardo;Soledad Izquierdo, Maria
关于长链多不饱和脂肪酸（LCPUFA）对神经元发育和功能的具体影响的信息有限。缺乏这些必需脂肪酸会损害鱼类的逃避和回避行为，其中Mauthner细胞（M细胞）在启动这种反应中发挥特别重要的作用。用响亮的刺激物对饲喂两种不同LCPUFA配置文件的金头鲷幼虫进行了挑战。投喂n-3 LCPUFA可增加鱼组织中这些脂肪酸的含量，并使更多的仔鱼对刺激作出快速的爆发性游泳速度反应。喂食n-3 LCPUFA的鱼的这种更快的惊吓反应也与免疫阳性神经反应的增加有关，特别是在M细胞中，这表明乙酰胆碱的产量更高。本研究首次证明了n-3 LCPUFA对鱼类特定神经元功能的影响，即M细胞和它们调节以逃避声音刺激的行为反应。
There is limited information on the specific effects of long-chain PUFA (LCPUFA) on neuron development and functioning. Deficiency of those essential fatty acids impairs escape and avoidance behaviour in fish, where Mauthner cells (M-cells) play a particularly important role in initiating this response. Gilthead seabream larvae fed two different LCPUFA profiles were challenged with a sonorous stimulus. Feeding n-3 LCPUFA increased the content of these fatty acids in fish tissues and caused a higher number of larvae to react to the stimulus with a faster burst swimming speed response. This faster startle response in fish fed n-3 LCPUFA was also associated with an increased immune-positive neural response, particularly in M-cells, denoting a higher production of acetylcholine. The present study shows the first evidence of the effect of n-3 LCPUFA on the functioning of particular neurons in fish, the M-cells and the behaviour response that they modulate to escape from a sound stimulus.