Prevalence and patterns of anti-nuclear antibodies in Korean children with juvenile idiopathic arthritis according to ILAR criteria
Prevalence and patterns of anti-nuclear antibodies in Korean children with juvenile idiopathic arthritis according to ILAR criteria
复制标题
DOI：
10.1080/03009740801998762
复制
发表时间：
2008-01-01
影响因子：
2.1
通讯作者：
Kim, D. S.
中科院分区：
文献类型：
--
作者：
Shin, J. I.;Kim, K. H.;Kim, D. S.
目的：研究抗核抗体（ANA）在不同亚型幼年特发性关节炎（JIA）中的患病率和模式，根据国际风湿病协会联盟（ILAR）的criteria.Methods：153例韩国JIA患者（男：女83：70）在1990年至2006年随访，并采用间接免疫荧光法以HEp-2细胞为底物检测ANA。37例患者在病程中重复ANA检测。结果：ANA在1：40或更高稀释度时阳性率为33%（50/153），其中1：40为70%，1：80为2%，1：160为16%，1：320为2%，1：640为10%。免疫荧光染色均质型占50%，斑点型占38%，核仁型占8%，着丝粒型占4%。随访期间，37例患者中有25例（68%）ANA滴度降低，14例（38%）核荧光模式改变。ANA血清阳性与女性性别（p < 0.0001）、HLA-B27阴性（p=0.01）和随访时红细胞沉降率（ESR）持续升高（p=0.014）相关。此外，高ANA滴度（1：160）与不良临床结局（随访时活动患者）相关（p=0.005）。结论：ANA可能是JIA患者疾病活动的重要标志物。ANA滴度在疾病缓解期间倾向于降低，但荧光模式似乎与疾病活动或临床结果无关。
Objectives: To investigate the prevalence and patterns of anti-nuclear antibodies (ANA) in different subtypes of juvenile idiopathic arthritis (JIA) according to the International League of Associations for Rheumatology (ILAR) criteria.Methods: One hundred and fifty-three Korean patients (M:F 83:70) with JIA were followed between 1990 and 2006 and were tested for ANA by an indirect immunofluorescence method using HEp-2 cells as the substrate. ANA tests were repeated in 37 patients during the course of the disease. The median age at onset was 7.5 years (range 0.8-15.9 years).Results: ANA were positive in 50 (33%) of the 153 patients at a dilution of 1:40 or higher (1:40 in 70%, 1:80 in 2%, 1:160 in 16%, 1:320 in 2%, and 1:640 in 10%). The patterns of immunofluorescence staining were homogeneous in 50%, speckled in 38%, nucleolar in 8%, and centromere in 4%. ANA titres were decreased in 25 (68%) of the 37 patients, and the nuclear fluorescence patterns changed in 14 (38%) during follow-up. ANA seropositivity was associated with female sex (p < 0.0001), negative HLA-B27 (p=0.01), and a persistently elevated erythrocyte sedimentation rate (ESR) at follow-up (p=0.014). Furthermore, a high ANA titre (1:160) was associated with a poor clinical outcome (active patients at follow-up) (p=0.005).Conclusions: ANA may be an important marker of disease activity in patients with JIA. ANA titres tend to decrease during disease remission but the fluorescence patterns do not appear to be related to disease activity or clinical outcome.