Characterization of an alginate-based drug delivery system for neurological applications
Characterization of an alginate-based drug delivery system for neurological applications
复制标题
DOI：
10.1016/j.medengphy.2007.10.003
复制
发表时间：
2008-09-01
影响因子：
2.2
通讯作者：
Dario, Paolo
中科院分区：
文献类型：
--
作者：
Ciofani, Gianni;Raffa, Vittoria;Dario, Paolo
本文介绍了一种基于海藻酸盐凝胶的给药系统。海藻酸盐系统的生物相容性、大小和形状的灵活性以及捕获生物分子的能力使其成为体内药物输送的理想选择。具体来说，通过考虑神经再生和神经保护的目标应用，必须解决生物相容性以及形态相容性（例如植入物的形状和大小）的问题。作者描述了各种类型的海藻酸盐凝胶；初步体内实验结果表明，从实现简单、插入和释放效果等方面考虑，圆柱形纤维是最佳选择。因此，我们在体外测试了纤维的释放并建立了理论模型，以获得释放动力学与影响实现过程的关键参数之间的数学相关性。(c) 2007年度。Elsevier Ltd.出版。版权所有。
This paper presents a drug delivery system based on alginate gels. The biocompatibility, the flexibility in size and shape, and the ability to entrap biomolecules make alginate-based systems ideal for in vivo drug delivery. Specifically, by considering the target application of neural regeneration and neuroprotection, the issue of biocompatibility as well as morphologic compatibility (e.g. shape and size of an implant) have to be addressed.The authors describe various types of alginate gels; fibers of cylindrical shape resulted the best choice in terms of simplicity of realization, insertion and release effectiveness, as shown by preliminary in vivo assays. Consequently, fibers release is tested in vitro and theoretically modelled, in order to obtain mathematical correlations between the release kinetics and key parameters affecting the realization procedure. (C) 2007 IPEM. Published by Elsevier Ltd. All rights reserved.