Nitric oxide effects on myocardial function and force-interval relations: Regulation of twitch duration
Nitric oxide effects on myocardial function and force-interval relations: Regulation of twitch duration
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DOI：
10.1006/jmcc.1999.1038
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发表时间：
1999-12-01
影响因子：
5
通讯作者：
Frosto, T
中科院分区：
文献类型：
--
作者：
Prabhu, SD;Azimi, A;Frosto, T
由于一氧化氮（NO）作为心肌收缩调节剂的确切作用以及力-间期关系尚不清楚，本研究的目的是检查NO供体S-亚硝基-N-乙酰基-青霉胺（SNAP）对基线心肌收缩的影响，以及SNAP和NO合酶（NOS）抑制剂N-G-硝基-L-精氨酸甲酯（L-NAME）对力-间期关系的影响，使用离体大鼠乳头肌进行研究。在存在NOS阻断的基础上，纳摩尔至微摩尔浓度的SNAP产生适度的正性肌力作用，使收缩等长肌张力增加（P <0.05）。
As the precise role of nitric oxide (NO) as a modulator of myocardial contraction and the force-interval relationship remains unclear, the objective of this study was to examine the effect of the NO donor S-nitroso-N-acetyl-penicillamine (SNAP) on baseline myocardial contraction, and the impact of both SNAP and the NO synthase (NOS) inhibitor N-G-nitro-L-arginine methyl ester (L-NAME) on the force interval relation,Studies were performed using isolated rat papillary muscles. In the presence of baseline NOS blockade, nanomolar to micromolar concentrations of SNAP exerted a modest positive inotropic effect with a small but significant increase in twitch isometric tension (P