SEGMENTAL VARIATION IN MICROSTRUCTURE, MATRIX SYNTHESIS AND CELL-PROLIFERATION IN RABBIT FLEXOR TENDON
SEGMENTAL VARIATION IN MICROSTRUCTURE, MATRIX SYNTHESIS AND CELL-PROLIFERATION IN RABBIT FLEXOR TENDON
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DOI：
10.3109/02844318909075117
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发表时间：
1989-01-01
影响因子：
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通讯作者：
LOHMANDER, LS
中科院分区：
文献类型：
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作者：
ABRAHAMSSON, SO;LUNDBORG, G;LOHMANDER, LS
为研究兔前掌深屈肌腱的基质合成和细胞增殖，设计了一套实验培养系统。特别注意三个连续确定的肌腱节段与肌腱鞘区域之间的差异。肌腱内有两个软骨区，一个在近端的背侧，一个在远端的掌侧。中间段由规则的肌腱组织组成。在远端节段的背侧，与长静脉入口相关的富含细胞的区域是进一步的特征。蛋白多糖的体外合成近端和远端段高于中间段，而胶原蛋白的合成以中间腱段最高。胶原含量的变化反映在胶原合成的变化上。中间段细胞增殖率最高。节段性生化特征与深屈肌腱的形态变异有很好的相关性。这些变化可能反映了对作用在肌腱上的不同机械力的适应。节段性变异也可能与屈肌腱的愈合能力有关。
An experimental culture system was designed with the purpose of studying matrix synthesis and cell proliferation in the deep flexor tendon of the rabbit forepaw. Special attention was paid to differences between three consecutive defined segments of the tendon from the region of the tendon sheath. There were two fribrocartilaginous areas in the tendon, one on the dorsal part of the proximal segment and one in the volar part of the distal segment. The intermediate segment consisted of regular tendinous tissue. The dorsal aspect of the distal segment was further characterized by a cell rich area related to the entrance of the vinculum longum. Proteoglycan synthesis in vitro was higher in the proximal and distal segments than in the intermediate, while collagen synthesis was highest in the intermediate tendinous segment. Variations in collagen content were reflected in variations in collagen synthesis. The rate of cell proliferation was highest in the intermediate segment. Segmental biochemical characteristics correlated well with morphological variations of the deep flexor tendon. These variations may reflect an adaptation to different mechanical forces acting on the tendon. The segmental variations may also be relevant for the healing capacity of the flexor tendon.