Circadian misalignment: A biological basis for mood vulnerability in shift work
Circadian misalignment: A biological basis for mood vulnerability in shift work
复制标题
DOI：
10.1111/ejn.14871
复制
发表时间：
2020-10-01
影响因子：
3.4
通讯作者：
Chellappa, Sarah L.
中科院分区：
文献类型：
--
作者：
Chellappa, Sarah L.
背景大约五分之一的工人从事夜班工作。流行病学研究表明，夜班工人患精神疾病的风险要高出25%-30%，包括抑郁和焦虑，这对劳动力来说是越来越重要的社会经济负担。因此，确定倒班工作如何对情绪产生负面影响是很重要的，因为这将有助于确定夜班工人患情绪障碍的更高风险背后的机制。方法这份意见讨论了最近发现的潜在的生物学机制--包括昼夜节律系统的作用和昼夜节律失调--潜在的倒班工人情绪易损性。研究包括最近的流行病学、人类实验室研究和动物在夜班工作或昼夜节律失调方面的临床前工作。这里讨论的目标生物学机制包括昼夜节律失调对大脑活动和脑肠轴的影响，这是情绪调节所必需的。结果昼夜节律失调对应于生物(昼夜节律)系统和日常睡眠-觉醒行为之间的失调，会对情绪调节的情绪水平和皮层活动产生不利影响。此外，动物临床前研究表明，当动物受到昼夜节律干扰时，脑肠轴功能不仅与情绪调节有关，还会扰乱情绪调节所必需的特定代谢物。结论昼夜节律失调是影响倒班工人情绪的一个重要机制。因此，了解它的作用并应用睡眠/昼夜行为干预来减轻昼夜节律失调对情绪的不利影响，有可能改善轮班工人的生活质量，这与情绪和睡眠质量密切相关。
Background Approximately one in five workers perform night shift work. Epidemiological studies suggest that night shift workers are at a 25-30% higher risk for mental illnesses, including depression and anxiety, which is an increasingly important socioeconomic burden for the workforce. Thus, it is important to determine how shift work negatively affects mood, as it will help identify mechanisms that underlie a night shift worker's higher risk for developing mood disturbances. Methods This opinion discusses recently identified, potential biological mechanisms-including the role of the circadian system and circadian misalignment-underlying mood vulnerability in shift workers. Studies included are recent epidemiological, human laboratory studies and animal preclinical work on night shift work or circadian misalignment. Target biological mechanisms of interest discussed here include circadian misalignment effects on brain activity and brain-gut axis, essential for mood regulation. Results Circadian misalignment, which corresponds to the misalignment between biological (circadian) system and daily sleep-wake behaviours, can adversely affect mood levels and cortical activity underlying mood regulation. Furthermore, animal preclinical work shows that the brain-gut axis function is not only implicated in mood regulation but can disrupt specific metabolites essential for mood regulation when animals are exposed to circadian disruption. Conclusions Circadian misalignment is a key mechanism underlying mood in e.g. shift workers. Therefore, understanding its role and applying sleep/circadian behavioural interventions to mitigate the adverse consequences of circadian misalignment on mood have the potential to improve quality of life, which is tightly associated with mood and sleep quality, in shift workers.